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CTF8

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CHTF8
Identifiers
AliasesCHTF8, CTF8, DERPC, chromosome transmission fidelity factor 8
External IDsOMIM: 613202; MGI: 2443370; HomoloGene: 84588; GeneCards: CHTF8; OMA:CHTF8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039690
NM_001040145
NM_001040146
NM_017804

NM_145412
NM_001364186

RefSeq (protein)

NP_001034779
NP_001035236
NP_001034779.1
NP_001035236.1

NP_663387
NP_001351115
NP_663387.3

Location (UCSC)Chr 16: 69.12 – 69.13 MbChr 8: 107.61 – 107.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromosome transmission fidelity protein 8 homolog is a protein that in humans is encoded by the CHTF8 gene.[5][6]

This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair.

This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternative splicing results in multiple variants encoding different isoforms. This gene has a pseudogene on chromosome X.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168802Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046691Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Merkle CJ, Karnitz LM, Henry-Sanchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". J Biol Chem. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
  6. ^ a b "Entrez Gene: CTF8 chromosome transmission fidelity factor 8 homolog (S. cerevisiae)".
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Further reading

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