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CTDP1

From Wikipedia, the free encyclopedia
CTDP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTDP1, CCFDN, FCP1, CTD phosphatase subunit 1
External IDsOMIM: 604927; MGI: 1926953; HomoloGene: 31254; GeneCards: CTDP1; OMA:CTDP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202504
NM_004715
NM_048368
NM_001318511

NM_026295

RefSeq (protein)

NP_001189433
NP_001305440
NP_004706
NP_430255

NP_080571

Location (UCSC)Chr 18: 79.68 – 79.75 MbChr 18: 80.45 – 80.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.[5][6][7]

This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.[7]

Interactions

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CTDP1 has been shown to interact with WD repeat-containing protein 77,[8] GTF2F1[6] and POLR2A.[9]

References

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  1. ^ a b c ENSG00000060069 GRCh38: Ensembl release 89: ENSG00000282752, ENSG00000060069Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033323Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J (Feb 1998). "An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 94 (26): 14300–5. Bibcode:1997PNAS...9414300A. doi:10.1073/pnas.94.26.14300. PMC 24951. PMID 9405607.
  6. ^ a b Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (Nov 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J Biol Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
  7. ^ a b "Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1".
  8. ^ Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3). England: 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.
  9. ^ Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11). UNITED STATES: 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMC 20825. PMID 9159119.
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Further reading

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