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CROT (gene)

From Wikipedia, the free encyclopedia
CROT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCROT, COT, carnitine O-octanoyltransferase
External IDsOMIM: 606090; MGI: 1921364; HomoloGene: 10899; GeneCards: CROT; OMA:CROT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143935
NM_001243745
NM_021151

NM_023733

RefSeq (protein)

NP_001137407
NP_001230674
NP_066974

NP_076222

Location (UCSC)Chr 7: 87.35 – 87.4 MbChr 5: 9.02 – 9.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxisomal carnitine O-octanoyltransferase is an enzyme that in humans is encoded by the CROT gene.[5][6]

Carnitine octanoyltransferase (EC 2.3.1.137) is a carnitine acyltransferase that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. This enzyme regulates the breakdown of Very Long Chain Fatty Acids (VLCFA) by performing a crucial step in the transport of medium length acyl chains out of the mammalian peroxisome to the cytosol and mitochondria for further breakdown. See also CRAT (MIM 600184). Van der Leij et al. (2000) reviewed the function, structural features, and phylogenetics of human carnitine acyltransferase genes, including CROT.[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000005469Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003623Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ferdinandusse S, Mulders J, IJlst L, Denis S, Dacremont G, Waterham HR, Wanders RJ (Oct 1999). "Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids". Biochem Biophys Res Commun. 263 (1): 213–8. doi:10.1006/bbrc.1999.1340. PMID 10486279.
  6. ^ a b "Entrez Gene: CROT carnitine O-octanoyltransferase".
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Further reading

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