CNTNAP4

CNTNAP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NXQ
Identifiers
Aliases	CNTNAP4, CASPR4, contactin associated protein like 4, contactin associated protein family member 4
External IDs	OMIM: 610518; MGI: 2183572; HomoloGene: 24912; GeneCards: CNTNAP4; OMA:CNTNAP4 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	76,560,757 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	113,609,349 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; corpus callosum; ; endothelial cell; ; inferior ganglion of vagus nerve; ; Pons; ; substantia nigra; ; subthalamic nucleus; ; Medulla Oblongata; ; Hypothalamus; ; cerebellar hemisphere;
	Top expressed in
	substantia nigra; ; ventral tegmental area; ; pontine nuclei; ; central gray substance of midbrain; ; dorsomedial hypothalamic nucleus; ; cerebellar cortex; ; habenula; ; trigeminal ganglion; ; retinal pigment epithelium; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; dendrite; synapse; presynaptic membrane; membrane; GABA-ergic synapse; integral component of presynaptic membrane;
Biological process	regulation of synaptic transmission, dopaminergic; regulation of grooming behavior; cell adhesion; regulation of synaptic transmission, GABAergic; regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologs
	85445
	170571
	ENSG00000152910
	ENSMUSG00000031772
	Q9C0A0
	Q99P47
NM_033401; NM_138994; NM_001322178; NM_001322179; NM_001322180;
	NM_001322181; NM_001322187; NM_001322188; NM_001322189; NM_001322190; NM_001322191
	NM_130457
NP_001309107; NP_001309108; NP_001309109; NP_001309110; NP_001309116;
	NP_001309117; NP_001309118; NP_001309119; NP_001309120; NP_207837; NP_620481
	NP_569724
	Wikidata
View/Edit Human	View/Edit Mouse

Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.^[5]^[6]

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152910 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031772 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (Jul 2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains". Mol Cell Neurosci. 20 (2): 283–97. doi:10.1006/mcne.2002.1110. PMID 12093160. S2CID 25024421.
^ ^a ^b "Entrez Gene: CNTNAP4 contactin associated protein-like 4".

External links

Human CNTNAP4 genome location and CNTNAP4 gene details page in the UCSC Genome Browser.

Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152910 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031772 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12093160-5] Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (Jul 2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains". Mol Cell Neurosci. 20 (2): 283–97. doi:10.1006/mcne.2002.1110. PMID 12093160. S2CID 25024421.

[entrez-6] "Entrez Gene: CNTNAP4 contactin associated protein-like 4".

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References

External links

Further reading