CHST11

CHST11
Identifiers
Aliases	CHST11, C4ST, C4ST-1, C4ST1, HSA269537, carbohydrate (chondroitin 4) sulfotransferase 11, carbohydrate sulfotransferase 11, OCBMD
External IDs	OMIM: 610128; MGI: 1927166; HomoloGene: 56808; GeneCards: CHST11; OMA:CHST11 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	104,762,014 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	83,031,734 bp
RNA expression pattern
	Top expressed in
	tibia; ; blood; ; cartilage tissue; ; monocyte; ; bone marrow cells; ; ventricular zone; ; granulocyte; ; amniotic fluid; ; trabecular bone; ; internal globus pallidus;
	Top expressed in
	cumulus cell; ; molar; ; fossa; ; medial dorsal nucleus; ; condyle; ; vestibular membrane of cochlear duct; ; substantia nigra; ; subiculum; ; median eminence; ; arcuate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activity; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; chondroitin 4-sulfotransferase activity;
Cellular component	Golgi apparatus; membrane; Golgi membrane; integral component of membrane;
Biological process	embryonic skeletal system morphogenesis; chondrocyte development; embryonic digit morphogenesis; negative regulation of apoptotic process; negative regulation of transforming growth factor beta receptor signaling pathway; post-embryonic development; respiratory gaseous exchange by respiratory system; cartilage development; developmental growth; regulation of cell population proliferation; embryonic limb morphogenesis; polysaccharide localization; post-anal tail morphogenesis; embryonic viscerocranium morphogenesis; carbohydrate biosynthetic process; chondroitin sulfate biosynthetic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	50515
	58250
	ENSG00000171310
	ENSMUSG00000034612
	Q9NPF2
	Q9JME2
	NM_018413; NM_001173982
	NM_021439
	NP_001167453; NP_060883; NP_060883.1
	NP_067414
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.^[5]^[6]

Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171310 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034612 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Jun 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". The Journal of Biological Chemistry. 275 (26): 20188–96. doi:10.1074/jbc.M002443200. PMID 10781601.
^ "Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11".
^ Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, et al. (Sep 2012). "Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study". Lancet. 380 (9844): 815–23. doi:10.1016/S0140-6736(12)60681-3. PMC 3443899. PMID 22763110.

External links

Human CHST11 genome location and CHST11 gene details page in the UCSC Genome Browser.

Yamauchi S, Mita S, Matsubara T, Fukuta M, Habuchi H, Kimata K, Habuchi O (Mar 2000). "Molecular cloning and expression of chondroitin 4-sulfotransferase". The Journal of Biological Chemistry. 275 (12): 8975–81. doi:10.1074/jbc.275.12.8975. PMID 10722746.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y, Habuchi O (Nov 2000). "Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase". Journal of Biochemistry. 128 (5): 763–70. doi:10.1093/oxfordjournals.jbchem.a022813. PMID 11056388.
Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (Sep 2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". The Journal of Biological Chemistry. 278 (38): 36115–27. doi:10.1074/jbc.M306044200. PMID 12847091.
Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS (Sep 2004). "Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32)". Oncogene. 23 (41): 6991–6. doi:10.1038/sj.onc.1207934. PMID 15273723.
Yamada T, Ohtake S, Sato M, Habuchi O (Dec 2004). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". The Biochemical Journal. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142. PMID 15324304.
Yusa A, Kitajima K, Habuchi O (May 2005). "N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1". The Biochemical Journal. 388 (Pt 1): 115–21. doi:10.1042/BJ20041573. PMC 1186699. PMID 15628971.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171310 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034612 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10781601-5] Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Jun 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". The Journal of Biological Chemistry. 275 (26): 20188–96. doi:10.1074/jbc.M002443200. PMID 10781601.

[entrez-6] "Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11".

[7] Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, et al. (Sep 2012). "Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study". Lancet. 380 (9844): 815–23. doi:10.1016/S0140-6736(12)60681-3. PMC 3443899. PMID 22763110.

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Clinical relevance

References

External links

Further reading