CFHR2

CFHR2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3ZD1, 5EA0
Identifiers
Aliases	CFHR2, CFHL2, FHR2, HFL3, complement factor H related 2
External IDs	OMIM: 600889; HomoloGene: 130536; GeneCards: CFHR2; OMA:CFHR2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	196,959,622 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; parietal pleura; ; mucosa of paranasal sinus; ; palpebral conjunctiva; ; skin of arm; ; buccal mucosa cell; ; gonad; ; testicle; ; visceral pleura; ; germinal epithelium;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; protein heterodimerization activity;
Cellular component	extracellular region; protein-containing complex;
Biological process	regulation of complement activation; negative regulation of protein binding; positive regulation of cytolysis;
	Sources:Amigo / QuickGO
Orthologs
	3080
	n/a
	ENSG00000080910
	n/a
	P36980
	n/a
	NM_001312672; NM_005666
	n/a
	NP_001299601; NP_005657
	n/a
	Wikidata
View/Edit Human

Complement factor H-related protein 2 is a protein that in humans is encoded by the CFHR2 gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080910 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Skerka C, Timmann C, Horstmann RD, Zipfel PF (Jun 1992). "Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes". J Immunol. 148 (10): 3313–8. doi:10.4049/jimmunol.148.10.3313. PMID 1533657. S2CID 25372557.
^ Skerka C, Moulds JM, Taillon-Miller P, Hourcade D, Zipfel PF (Oct 1995). "The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene". Immunogenetics. 42 (4): 268–74. doi:10.1007/bf00176444. PMID 7672821. S2CID 19760957.
^ "Entrez Gene: CFHR2 complement factor H-related 2".

External links

Human CFHR2 genome location and CFHR2 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P36980 (Complement factor H-related protein 2) at the PDBe-KB.

Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today. 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
Hageman GS, Hancox LS, Taiber AJ, et al. (2007). "Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications". Ann. Med. 38 (8): 592–604. doi:10.1080/07853890601097030. PMC 1905836. PMID 17438673.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701. S2CID 31776506.
Skerka C, Horstmann RD, Zipfel PF (1991). "Molecular cloning of a human serum protein structurally related to complement factor H". J. Biol. Chem. 266 (18): 12015–20. doi:10.1016/S0021-9258(18)99058-7. PMID 1711047.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080910 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1533657-3] Skerka C, Timmann C, Horstmann RD, Zipfel PF (Jun 1992). "Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes". J Immunol. 148 (10): 3313–8. doi:10.4049/jimmunol.148.10.3313. PMID 1533657. S2CID 25372557.

[pmid7672821-4] Skerka C, Moulds JM, Taillon-Miller P, Hourcade D, Zipfel PF (Oct 1995). "The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene". Immunogenetics. 42 (4): 268–74. doi:10.1007/bf00176444. PMID 7672821. S2CID 19760957.

[entrez-5] "Entrez Gene: CFHR2 complement factor H-related 2".

[1]

[2]

[3]

[4]

[5]

References

External links

Further reading