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CENTD2

From Wikipedia, the free encyclopedia
ARAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARAP1, CENTD2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, cnt-d2
External IDsOMIM: 606646; MGI: 1916960; HomoloGene: 12326; GeneCards: ARAP1; OMA:ARAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015242
NM_001040118
NM_001135190
NM_001369489

NM_001040111
NM_001040112
NM_027180
NM_198096

RefSeq (protein)

NP_001035207
NP_001128662
NP_056057
NP_001356418

Location (UCSC)Chr 11: 72.69 – 72.79 MbChr 7: 101 – 101.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.[5]

Function

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The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186635Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032812Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CENTD2 centaurin, delta 2".
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Further reading

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