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Protein-coding gene in humans
Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene .[ 5] protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae . This protein is a HSP90 Co-chaperone [ 6] signal transduction . It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4 , CDK6 , SRC , RAF1 , MOK , as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.[ 7]
CDC37 has been shown to interact with:
Domain architecture [ edit ] CDC37 consists of three structural domains . The N-terminal domain binds to protein kinases .[ 16] Hsp90 chaperone (heat shock protein 90) binding domain.[ 17]
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