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Protein-coding gene in humans
Protein family
Protein domain
Protein domain
Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene .[ 5] protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae . This protein is a HSP90 Co-chaperone [ 6] signal transduction . It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4 , CDK6 , SRC , RAF1 , MOK , as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.[ 7]
CDC37 has been shown to interact with:
Domain architecture [ edit ] CDC37 consists of three structural domains . The N-terminal domain binds to protein kinases .[ 16] Hsp90 chaperone (heat shock protein 90) binding domain.[ 17]
^ a b c GRCh38: Ensembl release 89: ENSG00000105401 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019471 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Dai K, Kobayashi R, Beach D (September 1996). "Physical interaction of mammalian CDC37 with CDK4" . The Journal of Biological Chemistry . 271 (36): 22030–22034. doi :10.1074/jbc.271.36.22030 PMID 8703009 . ^ Mollapour M, Neckers L (March 2012). "Post-translational modifications of Hsp90 and their contributions to chaperone regulation" . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1823 (3): 648–655. doi :10.1016/j.bbamcr.2011.07.018 . PMC 3226900 PMID 21856339 . ^ "Entrez Gene: CDC37 cell division cycle 37 homolog (S. cerevisiae)" .^ Stepanova L, Leng X, Parker SB, Harper JW (June 1996). "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4" . Genes & Development . 10 (12): 1491–1502. doi :10.1101/gad.10.12.1491 PMID 8666233 . ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . ^ Lamphere L, Fiore F, Xu X, Brizuela L, Keezer S, Sardet C, et al. (April 1997). "Interaction between Cdc37 and Cdk4 in human cells" . Oncogene . 14 (16): 1999–2004. doi :10.1038/sj.onc.1201036 PMID 9150368 . ^ Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, et al. (January 2004). "The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)" . Cell . 116 (1): 87–98. doi :10.1016/S0092-8674(03)01027-4 PMID 14718169 . S2CID 797232 . ^ Silverstein AM, Grammatikakis N, Cochran BH, Chinkers M, Pratt WB (August 1998). "p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site" . The Journal of Biological Chemistry . 273 (32): 20090–20095. doi :10.1074/jbc.273.32.20090 PMID 9685350 . ^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology . 6 (2): 97–105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . ^ a b Chen G, Cao P, Goeddel DV (February 2002). "TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90" . Molecular Cell . 9 (2): 401–410. doi :10.1016/S1097-2765(02)00450-1 PMID 11864612 . ^ Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR (March 2003). "Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability" . The Biochemical Journal . 370 (Pt 3): 849–857. doi :10.1042/BJ20021813 . PMC 1223241 PMID 12489981 . ^ Kimura Y, Rutherford SL, Miyata Y, Yahara I, Freeman BC, Yue L, et al. (July 1997). "Cdc37 is a molecular chaperone with specific functions in signal transduction" . Genes & Development . 11 (14): 1775–1785. doi :10.1101/gad.11.14.1775 PMID 9242486 . ^ Turnbull EL, Martin IV, Fantes PA (August 2005). "Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90" . The FEBS Journal . 272 (16): 4129–4140. doi :10.1111/j.1742-4658.2005.04825.x PMID 16098195 . S2CID 23442218 .
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