CDC25B

CDC25B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CWR, 1CWS, 1CWT, 1QB0, 1YM9, 1YMD, 1YMK, 1YML, 1YS0, 2A2K, 2IFD, 2IFV, 2UZQ, 3FQT, 3FQU, 4WH7, 4WH9
Identifiers
Aliases	CDC25B, cell division cycle 25B
External IDs	OMIM: 116949; MGI: 99701; HomoloGene: 41451; GeneCards: CDC25B; OMA:CDC25B - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	3,806,121 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	131,040,417 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right lung; ; right hemisphere of cerebellum; ; gastric mucosa; ; upper lobe of left lung; ; oocyte; ; stromal cell of endometrium; ; secondary oocyte; ; lymph node; ; anterior pituitary;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; blood; ; tibiofemoral joint; ; ventricular zone; ; lip; ; human fetus; ; spleen; ; thymus; ; granulocyte; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein tyrosine phosphatase activity; hydrolase activity; protein kinase binding; phosphoprotein phosphatase activity;
Cellular component	cytosol; centrosome; spindle pole; intracellular anatomical structure; microtubule organizing center; cytoskeleton; nucleus; nucleoplasm; cytoplasm;
Biological process	protein dephosphorylation; positive regulation of mitotic cell cycle; cell division; positive regulation of cytokinesis; protein phosphorylation; G2/M transition of mitotic cell cycle; oocyte maturation; positive regulation of cell population proliferation; cell cycle; female meiosis I; positive regulation of protein kinase activity; peptidyl-tyrosine dephosphorylation; positive regulation of cell cycle G2/M phase transition; mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	994
	12531
	ENSG00000101224
	ENSMUSG00000027330
	P30305
	P30306
NM_001287516; NM_001287517; NM_001287518; NM_001287519; NM_001287520;
	NM_001287522; NM_001287524; NM_004358; NM_021872; NM_021873; NM_021874; NM_212530
	NM_001111075; NM_023117
NP_001274445; NP_001274446; NP_001274447; NP_001274448; NP_001274449;
	NP_001274451; NP_001274453; NP_004349; NP_068658; NP_068659
	NP_001104545; NP_075606
	Wikidata
View/Edit Human	View/Edit Mouse

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.^[5]

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.^[6]

Interactions

CDC25B has been shown to interact with MAPK14,^[7] Casein kinase 2, alpha 1,^[8] CHEK1,^[9] MELK,^[10] Estrogen receptor alpha,^[11] YWHAB,^[12]^[13] YWHAZ,^[12] YWHAH^[12] and YWHAE.^[12]^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101224 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Galaktionov K, Beach D (February 1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID 1836978. S2CID 9659637.
^ "Entrez Gene: CDC25B cell division cycle 25 homolog B (S. pombe)".
^ Bulavin DV, Higashimoto Y, Popoff I J, Gaarde W A, Basrur V, Potapova O, Appella E, Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. 411 (6833): 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. S2CID 4410763.
^ Theis-Febvre N, Filhol Odile, Froment Carine, Cazales Martine, Cochet Claude, Monsarrat Bernard, Ducommun Bernard, Baldin Véronique (January 2003). "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene. 22 (2): 220–32. doi:10.1038/sj.onc.1206107. ISSN 0950-9232. PMID 12527891. S2CID 11296989.
^ Sanchez Y, Wong C, Thoma R S, Richman R, Wu Z, Piwnica-Worms H, Elledge S J (September 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511.
^ Davezac N, Baldin Véronique, Blot Joëlle, Ducommun Bernard, Tassan Jean-Pierre (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. ISSN 0950-9232. PMID 12400006. S2CID 20678893.
^ Ma ZQ, Liu Z, Ngan E S, Tsai S Y (December 2001). "Cdc25B Functions as a Novel Coactivator for the Steroid Receptors". Mol. Cell. Biol. 21 (23): 8056–67. doi:10.1128/MCB.21.23.8056-8067.2001. ISSN 0270-7306. PMC 99972. PMID 11689696.
^ ^a ^b ^c ^d Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN 0950-9232. PMID 10713667. S2CID 5816838.
^ ^a ^b Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. Bibcode:1995PNAS...92.7892C. doi:10.1073/pnas.92.17.7892. ISSN 0027-8424. PMC 41252. PMID 7644510.

External links

Human CDC25B genome location and CDC25B gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101224 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1836978-5] Galaktionov K, Beach D (February 1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID 1836978. S2CID 9659637.

[entrez-6] "Entrez Gene: CDC25B cell division cycle 25 homolog B (S. pombe)".

[pmid11333986-7] Bulavin DV, Higashimoto Y, Popoff I J, Gaarde W A, Basrur V, Potapova O, Appella E, Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. 411 (6833): 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. S2CID 4410763.

[pmid12527891-8] Theis-Febvre N, Filhol Odile, Froment Carine, Cazales Martine, Cochet Claude, Monsarrat Bernard, Ducommun Bernard, Baldin Véronique (January 2003). "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene. 22 (2): 220–32. doi:10.1038/sj.onc.1206107. ISSN 0950-9232. PMID 12527891. S2CID 11296989.

[pmid9278511-9] Sanchez Y, Wong C, Thoma R S, Richman R, Wu Z, Piwnica-Worms H, Elledge S J (September 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511.

[pmid12400006-10] Davezac N, Baldin Véronique, Blot Joëlle, Ducommun Bernard, Tassan Jean-Pierre (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. ISSN 0950-9232. PMID 12400006. S2CID 20678893.

[pmid11689696-11] Ma ZQ, Liu Z, Ngan E S, Tsai S Y (December 2001). "Cdc25B Functions as a Novel Coactivator for the Steroid Receptors". Mol. Cell. Biol. 21 (23): 8056–67. doi:10.1128/MCB.21.23.8056-8067.2001. ISSN 0270-7306. PMC 99972. PMID 11689696.

[pmid10713667-12] Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN 0950-9232. PMID 10713667. S2CID 5816838.

[pmid7644510-13] Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. Bibcode:1995PNAS...92.7892C. doi:10.1073/pnas.92.17.7892. ISSN 0027-8424. PMC 41252. PMID 7644510.

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Interactions

References

Further reading

External links