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Protein-coding gene in the species Homo sapiens
CD160 antigen is a protein that in humans is encoded by the CD160 gene .[ 5] [ 6] [ 7]
CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.[ 7]
Clinical significance [ edit ]
CD160 is a ligand for HVEM , and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti- PD-1 antibodies.[ 8] CD160 has also been proposed as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000117281 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038304 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (Oct 1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes" . J Immunol . 161 (6): 2780–90. doi :10.4049/jimmunol.161.6.2780 . PMID 9743336 . S2CID 25536877 .
^ Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (Apr 1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells" . J Immunol . 162 (3): 1223–6. doi :10.4049/jimmunol.162.3.1223 . PMID 9973372 . S2CID 23169904 .
^ a b "Entrez Gene: CD160 CD160 molecule" .
^ Stecher, Carmen; Battin, Claire; Leitner, Judith; Zettl, Markus; Grabmeier-Pfistershammer, Katharina; H?ller, Christoph; Zlabinger, Gerhard J.; Steinberger, Peter (22 May 2017). "PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells" . Frontiers in Immunology . 8 : 572. doi :10.3389/fimmu.2017.00572 . PMC 5439058 . PMID 28588576 .
^ Chabot, Sophie; Jabrane-Ferrat, Nabila; Bigot, Karine; Tabiasco, Julie; Provost, Alexandra; Golzio, Muriel; Noman, Muhammad Zaeem; Giustiniani, J?r?me; Bellard, Elisabeth; Brayer, St?phanie; Aguerre-Girr, Maryse; Meggetto, Fabienne; Giuriato, Sylvie; Malecaze, Fran?ois; Galiacy, St?phane; Ja?s, Jean-Philippe; Chose, Olivier; Kadouche, Jean; Chouaib, Salem; Teissi?, Justin; Abitbol, Marc; Bensussan, Armand; Le Bouteiller, Philippe (9 May 2011). "A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor" . The Journal of Experimental Medicine . 208 (5): 973–986. doi :10.1084/jem.20100810 . PMC 3092350 . PMID 21482699 .
^ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome" . Am. J. Hum. Genet . 80 (2): 232–40. doi :10.1086/510919 . PMC 1785342 . PMID 17236129 .
Bensussan A, Gluckman E, el Marsafy S, et al. (1994). "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity" . Proc. Natl. Acad. Sci. U.S.A . 91 (19): 9136–40. Bibcode :1994PNAS...91.9136B . doi :10.1073/pnas.91.19.9136 . PMC 44762 . PMID 8090781 .
Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A (2002). "BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression" . Int. Immunol . 14 (5): 445–51. doi :10.1093/intimm/14.5.445 . PMID 11978774 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Tanaka J, Toubai T, Tsutsumi Y, et al. (2004). "Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells" . Blood . 104 (3): 768–74. doi :10.1182/blood-2003-11-3870 . PMID 15073036 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Barakonyi A, Rabot M, Marie-Cardine A, et al. (2004). "Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset" . J. Immunol . 173 (9): 5349–54. doi :10.4049/jimmunol.173.9.5349 . PMID 15494480 .
Abecassis S, Giustiniani J, Meyer N, et al. (2007). "Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation" . J. Invest. Dermatol . 127 (5): 1161–6. doi :10.1038/sj.jid.5700680 . PMID 17218942 .
Giustiniani J, Marie-Cardine A, Bensussan A (2007). "A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity" . J. Immunol . 178 (3): 1293–300. doi :10.4049/jimmunol.178.3.1293 . PMID 17237375 .
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