CCT7

CCT7
Identifiers
Aliases	CCT7, CCTETA, CCTH, NIP7-1, TCP1ETA, chaperonin containing TCP1 subunit 7
External IDs	OMIM: 605140; MGI: 107184; HomoloGene: 4694; GeneCards: CCT7; OMA:CCT7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.2 Start 73,233,420 bp End 73,253,021 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C3 Start 85,428,496 bp End 85,445,457 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone islet of Langerhans right testis left testis right adrenal gland right adrenal cortex left adrenal gland muscle of thigh gastrocnemius muscle Top expressed in primitive streak renal corpuscle medullary collecting duct medial ganglionic eminence hair follicle endothelial cell of lymphatic vessel ureter ascending aorta epiblast aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleotide binding identical protein binding ATP binding protein folding chaperone activity unfolded protein binding Cellular component cytoplasm mitochondrion cytosol cell body zona pellucida receptor complex microtubule extracellular exosome chaperonin-containing T-complex Biological process positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body positive regulation of telomere maintenance via telomerase toxin transport positive regulation of establishment of protein localization to telomere protein folding binding of sperm to zona pellucida protein stabilization 'de novo' protein folding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10574 12468 Ensembl ENSG00000135624 ENSMUSG00000030007 UniProt Q99832 P80313 RefSeq (mRNA) NM_001009570 NM_001166284 NM_001166285 NM_006429 NM_007638 RefSeq (protein) NP_001009570 NP_001159756 NP_001159757 NP_006420 NP_031664 Location (UCSC) Chr 2: 73.23 – 73.25 Mb Chr 6: 85.43 – 85.45 Mb PubMed search
Wikidata
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T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.

Function

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.

Interactions

CCT7 has been shown to interact with PPP4C.

External links

• Human CCT7 genome location and CCT7 gene details page in the UCSC Genome Browser.

Further reading

• Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. Bibcode:1994CBio....4...89K. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530. S2CID 31300131.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hynes G, Celis JE, Lewis VA, Carne A, U S, Lauridsen JB, Willison KR (Nov 1996). "Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits". Electrophoresis. 17 (11): 1720–7. doi:10.1002/elps.1150171109. PMID 8982604. S2CID 11257092.{{cite journal}}: CS1 maint: date and year (link)
• Liou AK, Willison KR (Jul 1997). "Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes". The EMBO Journal. 16 (14): 4311–6. doi:10.1093/emboj/16.14.4311. PMC 1170057. PMID 9250675.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yokota S, Yanagi H, Yura T, Kubota H (Sep 2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". European Journal of Biochemistry. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.{{cite journal}}: CS1 maint: date and year (link)
• Hanafy KA, Martin E, Murad F (Nov 2004). "CCTeta, a novel soluble guanylyl cyclase-interacting protein". The Journal of Biological Chemistry. 279 (45): 46946–53. doi:10.1074/jbc.M404134200. PMID 15347653.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.