CCNB1IP1

CCNB1IP1
Identifiers
Aliases	CCNB1IP1, C14orf18, HEI10, cyclin B1 interacting protein 1
External IDs	OMIM: 608249; MGI: 2685134; HomoloGene: 18819; GeneCards: CCNB1IP1; OMA:CCNB1IP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 20,311,368 bp End 20,333,312 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C1 Start 51,026,705 bp End 51,045,189 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary ganglionic eminence right ovary gastric mucosa cartilage tissue ventricular zone body of uterus apex of heart right auricle left ventricle Top expressed in epiblast fetal liver hematopoietic progenitor cell embryo morula spermatocyte primitive streak embryo blastocyst otic placode primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding ubiquitin protein ligase activity transferase activity Cellular component condensed nuclear chromosome synaptonemal complex nucleus chromosome Biological process reciprocal meiotic recombination chiasma assembly meiosis blastocyst formation protein ubiquitination spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57820 239083 Ensembl ENSG00000100814 ENSMUSG00000071470 UniProt Q9NPC3 D3Z3K2 RefSeq (mRNA) NM_182852 NM_021178 NM_182849 NM_182851 NM_001111119 RefSeq (protein) NP_067001 NP_878269 NP_878272 NP_001104589 Location (UCSC) Chr 14: 20.31 – 20.33 Mb Chr 14: 51.03 – 51.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM] It is considered a housekeeping gene.

External links

• Human CCNB1IP1 genome location and CCNB1IP1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Grönholm M, Muranen T, Toby GG, et al. (2006). "A functional association between merlin and HEI10, a cell cycle regulator". Oncogene. 25 (32): 4389–4398. doi:10.1038/sj.onc.1209475. PMID 16532029.