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Protein-coding gene in humans
Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[ 7]
Protein Interactions [ edit ]
CACYBP has been shown to interact with SKP1A [ 8] and SIAH1 .[ 5]
The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90 .[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000116161 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014226 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses" . Molecular Cell . 7 (5): 915–26. doi :10.1016/S1097-2765(01)00242-8 . PMID 11389839 .
^ Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (January 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)" . The Journal of Biological Chemistry . 278 (3): 1837–40. doi :10.1074/jbc.M210263200 . PMID 12421809 .
^ a b "Entrez Gene: CACYBP calcyclin binding protein" .
^ Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses" . Molecular Cell . 7 (5): 915–26. doi :10.1016/S1097-2765(01)00242-8 . PMID 11389839 .
^ Filipek, Anna; Leśniak, Wiesława (2018-12-29). "Aktualny pogląd na komórkową funkcję S100A6 i jego ligandów, CacyBP/SIP i Sgt1" . Postępy Biochemii (in Polish). 64 (3): 242–252. doi :10.18388/pb.2018_136 . ISSN 0032-5422 . PMID 30656909 .
Filipek A, Jastrzebska B, Nowotny M, Kwiatkowska K, Hetman M, Surmacz L, et al. (June 2002). "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells" . The Journal of Biological Chemistry . 277 (23): 21103–9. doi :10.1074/jbc.M111010200 . PMID 11927578 .
Liu WX, Wu J, Zhao Z, Zhou Y, Peng XZ, Yuan JG, Qiang BQ (March 2002). "[Cloning and expression of human calcyclin binding protein (hCacyBP) gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 (2): 181–6. PMID 12006993 .
Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (August 2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family" . The Journal of Biological Chemistry . 277 (32): 28848–52. doi :10.1074/jbc.M203602200 . PMID 12042313 .
Wu J, Tan X, Peng X, Yuan J, Qiang B (July 2003). "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells" . Journal of Biochemistry and Molecular Biology . 36 (4): 354–8. doi :10.5483/bmbrep.2003.36.4.354 . PMID 12895292 .
Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, et al. (October 2005). "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex" . The Journal of Biological Chemistry . 280 (40): 34278–87. doi :10.1074/jbc.M506707200 . PMID 16085652 .
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .
Sun S, Ning X, Liu J, Liu L, Chen Y, Han S, et al. (May 2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma". Biochemical and Biophysical Research Communications . 356 (4): 864–71. doi :10.1016/j.bbrc.2007.03.080 . PMID 17400182 .
PDB gallery
1x5m : Solution structure of the core domain of calcyclin binding protein; siah-interacting protein (SIP)
2a26 : Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein