PIBF1

PIBF1
Identifiers
Aliases	PIBF1, C13orf24, CEP90, PIBF, progesterone immunomodulatory binding factor 1, JBTS33
External IDs	OMIM: 607532; MGI: 1261910; HomoloGene: 4628; GeneCards: PIBF1; OMA:PIBF1 - orthologs
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 E2.2|14 49.27 cM Start 99,336,860 bp End 99,491,929 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve bronchial epithelial cell ganglionic eminence right lobe of thyroid gland stromal cell of endometrium right uterine tube left lobe of thyroid gland anterior pituitary canal of the cervix Top expressed in spermatocyte spermatid zygote genital tubercle tail of embryo secondary oocyte seminiferous tubule morula blastocyst granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-4 receptor binding protein binding Cellular component cytoplasm centrosome centriolar satellite extracellular region cytoskeleton nucleus extracellular space microtubule organizing center Biological process negative regulation of natural killer cell activation positive regulation of interleukin-10 production immune system process mitotic spindle assembly protein localization to centrosome mitotic metaphase plate congression negative regulation of prostaglandin biosynthetic process negative regulation of interleukin-12 production non-motile cilium assembly positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10464 52023 Ensembl n/a ENSMUSG00000022064 UniProt Q8WXW3 n/a RefSeq (mRNA) NM_006346 NM_001349655 NM_029320 NM_029454 RefSeq (protein) NP_006337 NP_001336584 n/a Location (UCSC) n/a Chr 14: 99.34 – 99.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Progesterone-induced-blocking factor 1 is a protein that in humans is encoded by the PIBF1 gene. It has been shown to localize to the centrosome and has also been named CEP90.

External links

• Human PIBF1 genome location and PIBF1 gene details page in the UCSC Genome Browser.

Further reading

• Szekeres-Bartho J, Barakonyi A, Par G, et al. (2001). "Progesterone as an immunomodulatory molecule". Int. Immunopharmacol. 1 (6): 1037–48. doi:10.1016/S1567-5769(01)00035-2. PMID 11407300.
• Szekeres-Bartho J, Varga P, Pejtsik B (1990). "ELISA test for the detection of an immunological blocking factor in human pregnancy serum". J. Reprod. Immunol. 16 (1): 19–29. doi:10.1016/0165-0378(89)90003-X. PMID 2600930.
• Szekeres-Bartho J, Faust Z, Varga P (1996). "The expression of a progesterone-induced immunomodulatory protein in pregnancy lymphocytes". Am. J. Reprod. Immunol. 34 (6): 342–8. doi:10.1111/j.1600-0897.1995.tb00962.x. PMID 8607938. S2CID 6397686.
• Check JH, Arwitz M, Gross J, et al. (1997). "Lymphocyte immunotherapy (LI) increases serum levels of progesterone induced blocking factor (PIBF)". Am. J. Reprod. Immunol. 37 (1): 17–20. doi:10.1111/j.1600-0897.1997.tb00188.x. PMID 9138449. S2CID 19773974.
• Check JH, Arwitz M, Gross J, et al. (1997). "Evidence that the expression of progesterone-induced blocking factor by maternal T-lymphocytes is positively correlated with conception". Am. J. Reprod. Immunol. 38 (1): 6–8. doi:10.1111/j.1600-0897.1997.tb00269.x. PMID 9266004. S2CID 26240194.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Polgar B, Kispal G, Lachmann M, et al. (2004). "Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor". J. Immunol. 171 (11): 5956–63. doi:10.4049/jimmunol.171.11.5956. PMID 14634107.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Polgár B, Nagy E, Mikó E, et al. (2005). "Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome". Biol. Reprod. 71 (5): 1699–705. doi:10.1095/biolreprod.104.030437. PMID 15269099.
• Lachmann M, Gelbmann D, Kálmán E, et al. (2004). "PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome". Int. J. Cancer. 112 (1): 51–60. doi:10.1002/ijc.20326. PMID 15305375.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kozma N, Halasz M, Palkovics T, Szekeres-Bartho J (2006). "The progesterone-induced blocking factor modulates the balance of PKC and intracellular Ca". Am. J. Reprod. Immunol. 55 (2): 122–9. doi:10.1111/j.1600-0897.2005.00337.x. PMID 16433831. S2CID 32668565.