Butyrophilin, subfamily 2, member A2

BTN2A2
Identifiers
Aliases	BTN2A2, BT2.2, BTF2, BTN2.2, Butyrophilin, subfamily 2, member A2, butyrophilin subfamily 2 member A2
External IDs	OMIM: 613591; MGI: 3606486; HomoloGene: 56012; GeneCards: BTN2A2; OMA:BTN2A2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 26,383,096 bp End 26,394,874 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 23,661,846 bp End 23,673,027 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx lymph node tonsil granulocyte appendix monocyte tendon of biceps brachii spleen pancreatic ductal cell cerebellar cortex Top expressed in embryo embryo secondary oocyte morula primary oocyte epiblast blastocyst primary visual cortex placenta hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling receptor binding Cellular component integral component of membrane membrane plasma membrane external side of plasma membrane cell surface Biological process negative regulation of activated T cell proliferation negative regulation of cellular metabolic process negative regulation of phosphatidylinositol 3-kinase signaling positive regulation of regulatory T cell differentiation regulation of immune response T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10385 238555 Ensembl ENSG00000124508 ENSMUSG00000053216 UniProt Q8WVV5 A4QPC6 RefSeq (mRNA) NM_001197237 NM_001197238 NM_001197239 NM_001197240 NM_006995 NM_181531 NM_001289614 NM_001289615 NM_175938 RefSeq (protein) NP_001184166 NP_001184167 NP_001184168 NP_001184169 NP_008926 NP_853509 NP_001184166.1 NP_008926.2 NP_001276543 NP_001276544 NP_787952 Location (UCSC) Chr 6: 26.38 – 26.39 Mb Chr 13: 23.66 – 23.67 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.

Function

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Further reading

• Cavaletto M, Giuffrida MG, Fortunato D, Gardano L, Dellavalle G, Napolitano L, Giunta C, Bertino E, Fabris C, Conti A (July 2002). "A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane". Proteomics. 2 (7): 850–6. doi:10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C. PMID 12124930. S2CID 25710334.
• Rhodes DA, Stammers M, Malcherek G, Beck S, Trowsdale J (February 2001). "The cluster of BTN genes in the extended major histocompatibility complex". Genomics. 71 (3): 351–62. doi:10.1006/geno.2000.6406. PMID 11170752.

External links

• BTN2A2 human gene location in the UCSC Genome Browser.
• BTN2A2 human gene details in the UCSC Genome Browser.