Belapectin

Belapectin
Clinical data
Other names	GR-MD-02; Galactoarabino-rhamnogalacturonate;
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name α-D-Galacturono-α-D-galacto-β-D-galacto-6-deoxy-α-L- manno-α-L-arabinan, (1→2),(1→3),(1→4)-, methyl ester;
CAS Number	1980787-47-0; 1604015-18-0;
UNII	K7ODU55HT6;

Belapectin (also known as GR-MD-02) is a galectin-3 inhibitor developed by Galectin Therapeutics that failed phase 3 clinical trials for the treatment of non-alcoholic steatohepatitis.^[1]^[2]^[3]^[4]

References

^ Mireku, Akosua (26 June 2023). "NASH drugs race to cross the finish line". Pharmaceutical Technology. Retrieved 21 October 2023.
^ Al Attar, Atef; Antaramian, Ani; Noureddin, Mazen (3 April 2021). "Review of galectin-3 inhibitors in the treatment of nonalcoholic steatohepatitis". Expert Review of Clinical Pharmacology. 14 (4): 457–464. doi:10.1080/17512433.2021.1894127.
^ Slack, R.J.; Mills, R.; Mackinnon, A.C. (January 2021). "The therapeutic potential of galectin-3 inhibition in fibrotic disease". The International Journal of Biochemistry & Cell Biology. 130: 105881. doi:10.1016/j.biocel.2020.105881.
^ Tapper, Elliot B.; Ufere, Nneka N.; Huang, Daniel Q.; Loomba, Rohit (May 2022). "Review article: current and emerging therapies for the management of cirrhosis and its complications". Alimentary Pharmacology & Therapeutics. 55 (9): 1099–1115. doi:10.1111/apt.16831. ISSN 0269-2813.

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