Jump to content

Basem Al-Shayeb

Add links
From Wikipedia, the free encyclopedia

Basem Al-Shayeb is an Egyptian American microbiologist who is a co-founder and the founding chief technology officer of Amber Bio[1], a biotechnology startup company in the San Francisco Bay Area which is developing multi-kilobase RNA editing therapies using CRISPR-Cas systems.[1][2][3][4]

He received his PhD in microbial biology[5][6] as a National Science Foundation Fellow at the University of California, Berkeley and Innovative Genomics Institute,[7] where he conducted his dissertation work in the lab of Jennifer Doudna, and in the Earth and Planetary Science Department advised by Jillian Banfield.[8] According to ORCID[9] records, he is an active peer reviewer for Nature Portfolio research for several journals including Nature, Nature Communications, and Multidisciplinary Journal of Microbial Ecology (ISME).

Research

[edit]

During his time at UC Berkeley, Al-Shayeb was first or co-first author on publications describing the discovery of the largest known bacteriophages reported in Nature,[10][11][12][13][14] the smallest CRISPR-Cas genome editing systems reported in Science Magazine and Cell [15][16][17][18] and a new form of extrachromosomal DNA elements, which Al-Shayeb and colleagues named "Borgs," [19][20][21] found in methane-oxidizing archaea (Methanoperedens spp.) reported in Nature.[22][23] Some of the aforementioned CRISPR-Cas enzymes were further licensed by Mammoth Biosciences for diagnostic and therapeutic development [24] and in partnership with Vertex[25], Bayer[26], and Regeneron[27] to boost precision of gene-editing "as well as easing delivery for use in actual living cells and combining different target edits in a so-called “multiplex” arrangement", as further referenced in the 2020 Nobel Prize Lecture[28]. Subsequently, he supervised research reporting a strategy for programmable editing of large RNA molecules.[29] He was listed in Forbes 30 Under 30 and Arab America's 30 Under 30 in 2021, [11][30] and Forbes All-Star Alumni in 2024 for his scientific contributions.[31]

References

[edit]
  1. ^ a b Rice, India. "This Startup Just Raised $26 Million To Develop Safer Gene Editing Tools". Forbes. Retrieved 2024-06-27.
  2. ^ "New RNA-Editing Company, Amber Bio, Launches Multi-Kilobase Editing Platform". GEN - Genetic Engineering and Biotechnology News. 2023-08-03. Retrieved 2024-06-27.
  3. ^ https://www.businesswire.com/news/home/20230803489484/en/Amber-Bio-Raises-26-Million-Seed-Financing-Co-Led-by-Playground-Global-and-Andreessen-Horowitz-to-Advance-New-RNA-Based-Gene-Editing-Platform
  4. ^ "RNA editing start-up Amber Bio launches with $26 million". Chemical & Engineering News. Retrieved 2024-06-27.
  5. ^ "ORCID". orcid.org. Retrieved 2024-08-17.
  6. ^ "Basem Al-Shayeb". Plant & Microbial Biology | University of California, Berkeley. Retrieved 2024-08-18.
  7. ^ "Meet an IGI Scientist: Basem Al-Shayeb". Innovative Genomics Institute (IGI). Retrieved 2022-03-13.
  8. ^ "Basem Al-Shayeb | Earth & Planetary Science". eps.berkeley.edu. Retrieved 2024-08-18.
  9. ^ "ORCID". orcid.org. Retrieved 2024-09-15.
  10. ^ Knapp, Alex. "30 Under 30 In Science 2021: Building Better Trees, Supernova Simulations And Holograms". Forbes. Retrieved 2024-09-15.
  11. ^ a b "Basem Al-Shayeb". Forbes. Retrieved 2022-03-13.
  12. ^ "Hundreds Of New Viruses With Enormous Genomes Blur The Boundaries Of Life". IFLScience. 2020-02-13. Retrieved 2024-09-15.
  13. ^ York, Ashley (April 2020). "Too big to be ignored". Nature Reviews Microbiology. 18 (4): 192. doi:10.1038/s41579-020-0341-z. ISSN 1740-1534. PMID 32066943.
  14. ^ Koumoundouros, Tessa (2020-02-13). "Scientists Discover Giant Viruses With Features Only Seen Before in Living Cells". ScienceAlert. Retrieved 2024-09-15.
  15. ^ "News: Tiny but Mighty: How Researchers Found a New Game-Changing CRISPR Tool". CRISPR Medicine. Retrieved 2024-08-15.
  16. ^ "New Compact Genome Editors Found in Viruses". Innovative Genomics Institute (IGI). Retrieved 2024-08-17.
  17. ^ Sanders, Robert (2020-07-16). "Megaphages harbor mini-Cas proteins ideal for gene editing". Berkeley News. Retrieved 2024-09-15.
  18. ^ Al-Shayeb, Basem; Skopintsev, Petr; Soczek, Katarzyna M.; Stahl, Elizabeth C.; Li, Zheng; Groover, Evan; Smock, Dylan; Eggers, Amy R.; Pausch, Patrick; Cress, Brady F.; Huang, Carolyn J.; Staskawicz, Brian; Savage, David F.; Jacobsen, Steven E.; Banfield, Jillian F. (2022-11-23). "Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors". Cell. 185 (24): 4574–4586.e16. doi:10.1016/j.cell.2022.10.020. ISSN 0092-8674. PMID 36423580.
  19. ^ "Scientists discover Borgs, DNA strands that assimilate genes from their hosts". Chemical & Engineering News. Retrieved 2024-08-17.
  20. ^ Rinke, Christian (October 2022). "Mystery find of microbial DNA elements called Borgs". Nature. 610 (7933): 635–637. Bibcode:2022Natur.610..635R. doi:10.1038/d41586-022-02975-3. PMID 36261713.
  21. ^ "Resistance is futile, because Star Trek's Borg are real and can assimilate DNA from microbes". SYFY Official Site. 2021-08-02. Retrieved 2024-09-15.
  22. ^ "Previously undiscovered DNA 'borgs' found on California wetlands". The Independent. 2021-07-30.
  23. ^ Huang, Lauren (2021-07-19). "UC Berkeley researchers discover unique DNA sequence with potential to combat climate change". www.dailycal.org. Retrieved 2024-09-15.
  24. ^ Etherington, Darrell (2020-08-12). "Mammoth Biosciences lands exclusive license to new CRISPR proteins that could boost gene editing precision". TechCrunch. Retrieved 2024-09-15.
  25. ^ "Jennifer Doudna's Mammoth Links with Vertex in $700 Million Ultra-Small CRISPR Deal". BioSpace. 2021-10-26. Retrieved 2024-09-15.
  26. ^ Liu, Angus. "JPM 2022: Bayer taps CRISPR science from Doudna's lab in $1B biobucks Mammoth gene therapy deal".
  27. ^ "Small Enzymes, Giant Leaps: CRISPR's Next-Generation Approach to Genetic Diseases". BioSpace. 2024-08-05. Retrieved 2024-09-15.
  28. ^ Grandin, Karl (2024-02-21). The Nobel Prizes 2020. World Scientific. ISBN 978-981-12-9012-1.
  29. ^ Borrajo, Jacob; Javanmardi, Kamyab; Griffin, James; St. Martin, Susan J.; Yao, David; Hill, Kaisle; Blainey, Paul C.; Al-Shayeb, Basem (2023-08-18). "Programmable multi-kilobase RNA editing using CRISPR-mediated trans-splicing". bioRxiv: 2023.08.18.553620. doi:10.1101/2023.08.18.553620. PMC 10462116. PMID 37645763.
  30. ^ "Arab America Foundation Announces 30 Under 30 Awardees-Class of 2021". Arab America. 2021-10-06. Retrieved 2022-10-04.
  31. ^ "Forbes 30 Under 30 2024: Science". Forbes. Retrieved 2024-08-17.
Retrieved from "https://wiki.riteme.site/w/index.php?title=Basem_Al-Shayeb&oldid=1246254263"