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Protein-coding gene in the species Homo sapiens
B3GNT2 Identifiers Aliases B3GNT2 External IDs OMIM : 605581 ; MGI : 1889505 ; HomoloGene : 4797 ; GeneCards : B3GNT2 ; OMA :B3GNT2 - orthologs Wikidata
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene .[ 5] [ 6] [ 7]
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein . It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000170340 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051650 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T (Mar 1999). "A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases" . Proc Natl Acad Sci U S A . 96 (2): 406–11. Bibcode :1999PNAS...96..406Z . doi :10.1073/pnas.96.2.406 PMC 15149 PMID 9892646 . ^ Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (May 2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family" . J Biol Chem . 276 (5): 3498–507. doi :10.1074/jbc.M004800200 PMID 11042166 . ^ a b "Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2" .
Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions". Biochim. Biophys. Acta . 1473 (1): 35–53. doi :10.1016/S0304-4165(99)00168-3 . PMID 10580128 . Ju T, Cummings RD (2003). "A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16613–8. doi :10.1073/pnas.262438199 PMC 139192 PMID 12464682 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Isshiki S, Kudo T, Nishihara S, et al. (2003). "Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins" . J. Biol. Chem . 278 (38): 36611–20. doi :10.1074/jbc.M302681200 PMID 12855703 . Hayashi N, Nakamori S, Okami J, et al. (2004). "Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue". Pathobiology . 71 (1): 26–34. doi :10.1159/000072959 . PMID 14555842 . S2CID 11013021 . Mare L, Trinchera M (2004). "Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans". Eur. J. Biochem . 271 (1): 186–194. doi :10.1046/j.1432-1033.2003.03919.x . PMID 14686931 . S2CID 38965439 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance" . Genome Biol . 5 (2): R8. doi :10.1186/gb-2004-5-2-r8 PMC 395752 PMID 14759258 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Zheng H, Li Y, Ji C, et al. (2005). "Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase". Mol. Biol. Rep . 31 (3): 171–5. doi :10.1023/B:MOLE.0000043552.32411.67 . PMID 15560372 . S2CID 22952647 . Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry" . J. Proteome Res . 4 (6): 2070–80. doi :10.1021/pr0502065 . PMC 1850943 PMID 16335952 .
