Astressin-B
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Formula | C183H305N47O55 |
Molar mass | 4043.727 g·mol−1 |
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Astressin-B is a nonselective corticotropin releasing hormone antagonist that reduces the synthesis of adrenocorticotropic hormone and cortisol.[1]
It reduces the synthesis of adrenocorticotropic hormone and improves the sexual drive of rats under stressing conditions.[2]
Astressin-B is able to delay the emptying of solid food in mice.[3] Astressin-B can prevent the release of adrenocorticotropic hormone in mice due to shock, alcohol and endotoxemia.[4]
Treatment with astressin-B caused the sudden growth of hair in mice bred for a propensity for stress.[5]
References
[edit]- ^ Vulliémoz NR, Xiao E, Xia-Zhang L, Rivier J, Ferin M (March 2008). "Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey". Endocrinology. 149 (3): 869–874. doi:10.1210/en.2007-1350. PMC 2275354. PMID 18063681.
- ^ Miwa Y, Nagase K, Oyama N, Akino H, Yokoyama O (March 2011). "Effect of corticotropin-releasing factor receptor antagonist on psychologically suppressed masculine sexual behavior in rats". The Journal of Sexual Medicine. 8 (3): 688–695. doi:10.1111/j.1743-6109.2010.02055.x. PMID 20946165.
- ^ Wang L, Martínez V, Rivier JE, Taché Y (November 2001). "Peripheral urocortin inhibits gastric emptying and food intake in mice: differential role of CRF receptor 2". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281 (5): R1401–R1410. doi:10.1152/ajpregu.2001.281.5.R1401. PMID 11641109.
- ^ Rivier CL, Grigoriadis DE, Rivier JE (June 2003). "Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors". Endocrinology. 144 (6): 2396–2403. doi:10.1210/en.2002-0117. PMID 12746300.
- ^ Wang L, Million M, Rivier J, Rivier C, Craft N, Stenzel-Poore MP, et al. (February 2011). Polymenis M (ed.). "CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice". PLOS ONE. 6 (2): e16377. Bibcode:2011PLoSO...616377W. doi:10.1371/journal.pone.0016377. PMC 3040186. PMID 21359208.