Alpiropride

Alpiropride
Clinical data
Trade names	Revistel, Rivistel, or Rivestel
Other names	Iristel; RIV-2093; RIV2093; RIV 2093; Riv 2093; Riv-2093; Riv2093
Drug class	Dopamine D2 receptor antagonist; Antihypertensive agent; Antimigraine agent
Identifiers
	IUPAC name 4-amino-2-methoxy-5-(methylsulfamoyl)-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]benzamide;
CAS Number	81982-32-3;
PubChem CID	71253;
ChemSpider	64384;
UNII	1768UW0XS1;
ChEBI	CHEBI:135599;
ChEMBL	ChEMBL2104024;
Chemical and physical data
Formula	C17H26N4O4S
Molar mass	382.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNS(=O)(=O)C1=C(C=C(C(=C1)C(=O)NCC2CCCN2CC=C)OC)N;
	InChI InChI=1S/C17H26N4O4S/c1-4-7-21-8-5-6-12(21)11-20-17(22)13-9-16(26(23,24)19-2)14(18)10-15(13)25-3/h4,9-10,12,19H,1,5-8,11,18H2,2-3H3,(H,20,22); Key:QRQMZZNDJGHPHZ-UHFFFAOYSA-N;

Alpiropride (INNTooltip International Nonproprietary Name; brand name Revistel, Rivistel, or Rivestel) is a dopamine D₂ receptor antagonist of the benzamide group related to sulpiride.^[1]^[2]^[3]^[4]^[5] It is described as an antihypertensive agent and has been marketed for use as an antimigraine medication in Portugal.^[1]^[4]^[2] The drug was first described by 1980^[1] and introduced for medical use by 1989.^[4] It remained marketed in Portugal as late as 2000.^[2]

References

^ ^a ^b ^c Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 33. ISBN 978-1-4757-2085-3. Retrieved 24 October 2024.
^ ^a ^b ^c Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Index nominum. Medpharm Scientific Publishers. p. 31. ISBN 978-3-88763-075-1. Retrieved 24 October 2024.
^ Milne, G.W.A. (2018). Drugs: Synonyms and Properties. Routledge Revivals. Taylor & Francis. p. 358. ISBN 978-1-351-78990-5. Retrieved 24 October 2024.
^ ^a ^b ^c Ong, Helen H.; Allen, Richard C. (1989). "Chapter 31. To Market, To Market -1988". Annual Reports in Medicinal Chemistry. Elsevier. p. 295–315. doi:10.1016/s0065-7743(08)60553-9. ISSN 0065-7743.
^ Current Medicinal Chemistry. Bentham Science Publishers. p. 275. Retrieved 24 October 2024.

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