Alkb homolog 3, alpha-ketoglutaratedependent dioxygenase

ALKBH3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IUW
Identifiers
Aliases	ALKBH3, ABH3, DEPC-1, DEPC1, PCA1, hABH3, alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase, alkB homolog 3, alpha-ketoglutaratedependent dioxygenase, alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
External IDs	OMIM: 610603; MGI: 1916363; HomoloGene: 16393; GeneCards: ALKBH3; OMA:ALKBH3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	43,920,274 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	93,841,152 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; Achilles tendon; ; muscle of thigh; ; gonad; ; gastrocnemius muscle; ; stromal cell of endometrium; ; islet of Langerhans; ; body of pancreas; ; skin of leg; ; left ovary;
	Top expressed in
	interventricular septum; ; seminiferous tubule; ; muscle of thigh; ; gastrocnemius muscle; ; soleus muscle; ; medial head of gastrocnemius muscle; ; triceps brachii muscle; ; lumbar spinal ganglion; ; skeletal muscle tissue; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; L-ascorbic acid binding; dioxygenase activity; metal ion binding; DNA-N1-methyladenine dioxygenase activity; oxidoreductase activity; ferrous iron binding; mRNA N1-methyladenosine dioxygenase activity; 2-oxoglutarate-dependent dioxygenase activity; cytosine C-5 DNA demethylase activity;
Cellular component	nucleus; mitochondrion; nucleoplasm; cytoplasm; cytosol;
Biological process	cell population proliferation; cellular response to DNA damage stimulus; DNA dealkylation involved in DNA repair; oxidative single-stranded DNA demethylation; oxidative single-stranded RNA demethylation; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	221120
	69113
	ENSG00000166199
	ENSMUSG00000040174
	Q96Q83
	Q8K1E6
	NM_139178
	NM_026944
	NP_631917
	NP_081220
	Wikidata
View/Edit Human	View/Edit Mouse

AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase is a protein that in humans is encoded by the ALKBH3 gene. ^[5]

Function

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166199 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040174 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase". Retrieved 2017-03-04.

Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G (2006). "Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage". EMBO J. 25 (14): 3389–97. doi:10.1038/sj.emboj.7601219. PMC 1523172. PMID 16858410.
Liu BQ, Wu YD, Li PH, Wei JX, Zhang T, Liu RL (2007). "Prostate cancer antigen-1 as a potential novel marker for prostate cancer". Asian J. Androl. 9 (6): 821–6. doi:10.1111/j.1745-7262.2007.00279.x. PMID 17968469.
Monsen VT, Sundheim O, Aas PA, Westbye MP, Sousa MM, Slupphaug G, Krokan HE (2010). "Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3". Nucleic Acids Res. 38 (19): 6447–55. doi:10.1093/nar/gkq518. PMC 2965238. PMID 20525795.
Chen B, Liu H, Sun X, Yang CG (2010). "Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3". Mol Biosyst. 6 (11): 2143–9. doi:10.1039/c005148a. PMID 20714506.
Malki K, Uher R, Paya-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng MY, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig IW, Lewis CM, McGuffin P, Schalkwyk LC (2011). "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants". Biol. Psychiatry. 69 (4): 360–5. doi:10.1016/j.biopsych.2010.08.011. PMID 20970119. S2CID 41571515.
Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N (2011). "ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer". Br. J. Cancer. 104 (4): 700–6. doi:10.1038/sj.bjc.6606012. PMC 3049579. PMID 21285982.
Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y (2011). "DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation". Mol. Cell. 44 (3): 373–84. doi:10.1016/j.molcel.2011.08.039. PMC 3258846. PMID 22055184.
Koike K, Ueda Y, Hase H, Kitae K, Fusamae Y, Masai S, Inagaki T, Saigo Y, Hirasawa S, Nakajima K, Ohshio I, Makino Y, Konishi N, Yamamoto H, Tsujikawa K (2012). "anti-tumor effect of AlkB homolog 3 knockdown in hormone- independent prostate cancer cells". Curr Cancer Drug Targets. 12 (7): 847–56. doi:10.2174/156800912802429283. PMID 22515525.
Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K, Nakajima Y (2012). "PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis". Cancer Res. 72 (18): 4829–39. doi:10.1158/0008-5472.CAN-12-0328. PMID 22826605. S2CID 134935.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166199 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040174 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase". Retrieved 2017-03-04.

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Function

References

Further reading