ASF1B

ASF1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5BNX, 5BO0
Identifiers
Aliases	ASF1B, CIA-II, anti-silencing function 1B histone chaperone
External IDs	OMIM: 609190; MGI: 1914179; HomoloGene: 56797; GeneCards: ASF1B; OMA:ASF1B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,136,613 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,696,826 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; mucosa of transverse colon; ; gonad; ; testicle; ; ventricular zone; ; blood; ; rectum; ; lymph node; ; bone marrow;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; secondary oocyte; ; zygote; ; tibiofemoral joint; ; primary oocyte; ; otic placode; ; thymus; ; somite; ; condyle; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone binding; protein binding;
Cellular component	chromatin; nucleus; nucleoplasm; protein-containing complex;
Biological process	multicellular organism development; DNA replication-dependent chromatin assembly; nucleosome assembly; cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; spermatogenesis; chromatin organization; blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
	55723
	66929
	ENSG00000105011; ENSG00000288210
	ENSMUSG00000005470
	Q9NVP2
	Q9DAP7
	NM_018154
	NM_024184
	NP_060624
	NP_077146
	Wikidata
View/Edit Human	View/Edit Mouse

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.^[5]^[6]^[7]

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.^[7]

Interactions

ASF1B has been shown to interact with TLK2,^[6]^[8] CHAF1B,^[5]^[8] TLK1^[6]^[8] and CHAF1A.^[5]^[8]

References

^ ^a ^b ^c ENSG00000288210 GRCh38: Ensembl release 89: ENSG00000105011, ENSG00000288210 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
^ ^a ^b ^c Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. Bibcode:2001CBio...11.1068S. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414. S2CID 8866062.
^ ^a ^b "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".
^ ^a ^b ^c ^d Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

Human ASF1B genome location and ASF1B gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000288210 GRCh38: Ensembl release 89: ENSG00000105011, ENSG00000288210 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11897662-5] Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.

[pmid11470414-6] Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. Bibcode:2001CBio...11.1068S. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414. S2CID 8866062.

[entrez-7] "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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Function

Interactions

References

Further reading

External links