Jump to content

6β-Hydroxyhyoscyamine epoxidase

From Wikipedia, the free encyclopedia
6β-Hydroxyhyoscyamine epoxidase
Identifiers
EC no.1.14.11.14
CAS no.121479-53-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a 6β-hydroxyhyoscyamine epoxidase (EC 1.14.11.14) is an enzyme that catalyzes the chemical reaction

(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 scopolamine + succinate + CO2 + H2O

The 3 substrates of this enzyme are (6S)-6-hydroxyhyoscyamine, 2-oxoglutarate, and O2, whereas its 4 products are scopolamine, succinate, CO2, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor. This enzyme participates in alkaloid biosynthesis ii. It has two cofactors: iron and ascorbate.

Nomenclature

[edit]

The systematic name of this enzyme class is (6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming). This enzyme is also called hydroxyhyoscyamine dioxygenase.

References

[edit]
  • Hashimoto T, Kohno J, Yamada Y (1989). "6β-Hydroxyhyoscyamine epoxidase from cultured roots of Hyoscyamus niger". Phytochemistry. 28 (4): 1077–1082. doi:10.1016/0031-9422(89)80186-4.