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Platelet-activating factor receptor

From Wikipedia, the free encyclopedia

PTAFR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTAFR, PAFR, platelet activating factor receptor
External IDsOMIM: 173393; MGI: 106066; HomoloGene: 20260; GeneCards: PTAFR; OMA:PTAFR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164723
NM_000952
NM_001164721
NM_001164722

NM_001081211

RefSeq (protein)

NP_000943
NP_001158193
NP_001158194
NP_001158195

NP_001074680

Location (UCSC)Chr 1: 28.15 – 28.19 MbChr 4: 132.29 – 132.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor.[5][6] It is encoded in the human by the PTAFR gene.

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.[8]

Ligands

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Agonists

Antagonists

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169403Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056529Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
  6. ^ Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68–69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
  7. ^ "Entrez Gene: PTAFR platelet-activating factor receptor".
  8. ^ Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis". Lab. Invest. 94 (4): 455–466. doi:10.1038/labinvest.2013.155. PMID 24492283.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.