Gostatin

Gostatin
Names
	IUPAC name 3-Amino-5-(carboxymethyl)-4-oxo-2,3-dihydro-1H-pyridine-6-carboxylic acid
Identifiers
CAS Number	78416-84-9 ;
3D model (JSmol)	Interactive image;
ChemSpider	91339;
PubChem CID	101100;
UNII	GNH8A5TAQ0;
	InChI InChI=UXFJYSFCCBPXED-UHFFFAOYSA-N Key: 1S/C8H10N2O5/c9-4-2-10-6(8(14)15)3(7(4)13)1-5(11)12/h4,10H,1-2,9H2,(H,11,12)(H,14,15);
	SMILES C1C(C(=O)C(=C(N1)C(=O)O)CC(=O)O)N;
Properties
Chemical formula	C8H10N2O5
Molar mass	214.177 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Gostatin is an irreversible inhibitor of the aspartate aminotransferase^[1]^[2] produced by the bacterium Streptomyces sumanensis.^[1]^[3] Its structure is a dihydro-4-pyridone analog of glutamic acid.

References

^ ^a ^b Lanthorn, T.H.; Fagg, G.E. (April 1989). "Gostatin blocks physiological actions and binding of acidic amino acids in rat brain". Neuropharmacology. 28 (4): 429–432. doi:10.1016/0028-3908(89)90041-5. PMID 2546088. S2CID 22246793.
^ Coombs, Graham H. (7 October 1991). Biochemical Protozoology As A Basis For Drug Design. CRC Press. p. 115. ISBN 978-0-7484-0001-0.
^ Meurant, Gerard (2 December 2012). Actinomycetes in Biotechnology. Elsevier. p. 304. ISBN 978-0-08-098433-9.