Exatecan
Appearance
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Names | |
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Preferred IUPAC name
(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione | |
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3D model (JSmol)
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CompTox Dashboard (EPA)
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Properties | |
C24H22FN3O4 | |
Molar mass | 435.455 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Exatecan is a drug which is a structural analog of camptothecin with antineoplastic activity.[1]
A derivative is used in Trastuzumab deruxtecan.
Synthesis
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Exatecan_scheme.png/600px-Exatecan_scheme.png)
References
[edit]- ^ Abou-Alfa, GK; Letourneau, R; Harker, G; Modiano, M; Hurwitz, H; Tchekmedyian, NS; Feit, K; Ackerman, J; De Jager, RL; Eckhardt, SG; O'Reilly, EM (20 September 2006). "Randomized Phase III Study of Exatecan and Gemcitabine Compared with Gemcitabine Alone in Untreated Advanced Pancreatic Cancer". Journal of Clinical Oncology. 24 (27): 4441–7. doi:10.1200/JCO.2006.07.0201. PMID 16983112.
- ^ H. Terasawa, A. Ejima, S. Ohsuki, K. Uoto, U.S. Patent 5,834,476 (1998).