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User:Andrew Su/ITK (gene)

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IL2-inducible T-cell kinase
1LUI
Available structures: 1lui​, 1luk​, 1lum​, 1lun​, 1sm2​, 1snu​, 1snx​, 2etz​, 2eu0
Identifiers
Symbols ITK; PSCTK2; EMT; LYK; MGC126257; MGC126258
External IDs OMIM: 186973 MGI96621 HomoloGene4051
EC number 2.7.10.2
RNA expression pattern

More reference expression data

Protein domains

Orthologs

Category:Human proteins

IL2-inducible T-cell kinase, also known as ITK, is a protein

which in humans is encoded by the ITK  gene.[1]

Function

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This gene encodes an intracellular tyrosine kinase

expressed in T-cell

s. The protein is thought to play a role in T-cell proliferation and differentiation.[2][3]

Structure

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This protein contains the following domains, which are often found in intracellular kinases:[4]

(pleckstrin homology domain)
– (Src homology 3)
– (Src homology 2)

Protein interactions

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The protein encoded by this gene has been found to interact with FYN , GRB2 , LAT , KHDRBS1 , KPNA2 , LCP2 , PPIA , PLCG1 , and WAS

in multiple protein interaction studies.[5]

References

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  1. ^ Gibson S, Leung B, Squire JA, Hill M, Arima N, Goss P, Hogg D, Mills GB (September 1993). "Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q". Blood. 82 (5): 1561–72. doi:10.1182/blood.V82.5.1561.1561. PMID 8364206.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)
  2. ^ Kosaka Y, Felices M, Berg LJ (October 2006). "Itk and Th2 responses: action but no reaction". Trends Immunol. 27 (10): 453–60. doi:10.1016/j.it.2006.08.006. PMID 16931156.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: ITK IL2-inducible T-cell kinase".
  4. ^ Hawkins J, Marcy A (July 2001). "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity". Protein Expr. Purif. 22 (2): 211–9. doi:10.1006/prep.2001.1447. PMID 11437596.{{cite journal}}: CS1 maint: date and year (link)
  5. ^ "The BioGRID | ITK - EG3702 : Homo sapiens search results". Retrieved 2009-01-28.

Further reading

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