CZIB
CZIB | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CZIB, chromosome 1 open reading frame 123, C1orf123, CXXC motif containing zinc binding protein | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1921348; HomoloGene: 41206; GeneCards: CZIB; OMA:CZIB - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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CZIB is a gene in the human genome that encodes the protein CXXC motif containing zinc binding protein. CZIB was previously referred to as C1orf123.
Gene
[edit]CZIB is a gene located in the human genome on the short arm of chromosome 1 at p32.2, between 53,679,771 base pairs and 53,686,289 base pairs. It is 6,519 bases long with 8 exons and encodes the C1orf123 protein, also known as UPF0587.[5]
Gene Neighborhood
The following genes are close to CZIB on chromosome 1
-LRP8:This gene encodes a member of the low density lipoprotein receptor (LDLR) family, a cell surface protein that plays a role in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation.[6]
-CPT2: This gene encodes a nuclear protein that is transported to the mitochondrial inner membrane.[7]
-MAGOH: Encodes protein that is a component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.[8]
-SLC1A7: Transports L-glutamate. Its associated chloride conductance may participate in visual processing.[9]
Protein
[edit]The CZIB protein is 160 amino acids in length and weighs 18.0 kdal.[5] It has an isoelectric point of 4.73 and belongs to the domain/family DUF866 which consists of many hypothetical eukaryotic proteins of unknown function, all of them with a length around 165 residues.[10] Aliases of the protein include FLJ20580 and UPF0587 Protein [11]
Homology
[edit]CZIB has many orthologs in close and distant species including primates, mammals, reptiles, birds, invertebrates, moss and yeast. The protein sequences are highly conserved throughout these species, although mRNA transcripts of the gene have only been found in primates. There are no paralogs of C1orf123.[12]
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Structure
[edit]The C1orf123 protein has no transmembrane regions so is therefore likely not a transmembrane protein. Three post-translational modification sites have been experimentally found, including a phosphotyrosine, phosphoserine, and glycyl-lysine isopeptide.[13] A portion of the 3' UTR of C1orf123 has 100% identity with the mRNA for Homo sapiens carnitine palmitoyltransferase 2 is a nuclear gene that encodes mitochondrial protein. This gene works with carnitine palmitoyltransferase I, and the encoded protein oxidizes long-chain fatty acids in the mitochondria.[14] C1orf123 protein secondary structure has been found to be very similar to that of MAL13P1.257 protein. C1orf123 protein is thought to have seven beta-sheet regions and one alpha helix region and according to the Phyre2 program, there is 100% confidence that the structure of 95% of the C1orf123 protein matches the hypothetical protein MAL13P1.257.[15] The MAL13P1.257 is a hypothetical conserved plasmodium protein of unknown function [16]
Gene expression
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/5/58/C1orf123_Hypoxic_Condition.png/220px-C1orf123_Hypoxic_Condition.png)
Various gene expression data has shown that "C1orf123" is expressed in varying amounts within the human body. It is most highly expressed in nerve and pituitary glands and not expressed in other body sites such as ear, esophagus, larynx, and tonsil.[17] When health states were compared for the expression of "C1orf123" it was found that expression of the gene increased in adrenal tumors and decreased to below normal levels in kidney and lung tumors. For developmental stages, "C1orf123" is most highly expressed in the fetus and not at all expressed in neonates and infants. For the most part, "C1orf123" is expressed in relatively average amounts in the human body with the exception of CD34+ and CD56+NK cells where expression is twice the amount of the average.[18] GEO profiles give some insight into the expression of "C1orf123" under varying conditions. Expression of the gene is seen to be absent under hypoxic conditions as seen in the figure below. GEO profiles also show that expression of "C1orf123" does not change in papillary thyroid cancer or chlamydia pneumonia infection.[19]
Clinical significance
[edit]The loss of the short arm of chromosome 1, the part of chromosome 1 that C1orf123 is located on, cause and parathyroid gland tumorigenesis resulting in hyperparathyroidism. 60% of the tumors tested showed an alteration on either 1p or the MEN1 locus or both. The conclusion of this study is that the short arm of chromosome 1 contains at least two different tumor suppressor genes involved in parathyroid tumorigenesis.[20]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000162384 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028608 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "C1orf123 Gene - GeneCards | CA123 Protein | CA123 Antibody". GeneCards. Retrieved 2013-09-22.
- ^ "LRP8 Gene - GeneCards | LRP8 Protein | LRP8 Antibody". GeneCards. Retrieved 2013-09-22.
- ^ "CPT2 Gene - GeneCards | CPT2 Protein | CPT2 Antibody". GeneCards. Retrieved 2013-09-22.
- ^ "MAGOH Gene - GeneCards | MGN Protein | MGN Antibody". GeneCards. Retrieved 2013-09-22.
- ^ "SLC1A7 Gene - GeneCards | EAA5 Protein | EAA5 Antibody". GeneCards. Retrieved 2013-09-22.
- ^ "Embl-Ebi". Ebi.ac.uk. Retrieved 2013-12-02.
- ^ "C1orf123 Gene - GeneCards | CA123 Protein | CA123 Antibody". GeneCards. Retrieved 2013-09-22.
- ^ [1] [dead link]
- ^ "dbPTM". Dbptm.mbc.nctu.edu.tw. Archived from the original on 2013-09-27. Retrieved 2013-09-22.
- ^ "Homo sapiens carnitine palmitoyltransferase 2 (CPT2), mRNA - Nucleotide - NCBI". Ncbi.nlm.nih.gov. 2013-03-25. Retrieved 2013-09-22.
- ^ Protein structure prediction on the web: a case study using the Phyre server Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009)
- ^ "MAL13P1.257 conserved Plasmodium protein, unknown function [Plasmodium falciparum 3D7] - Gene - NCBI". Ncbi.nlm.nih.gov. Retrieved 2013-09-22.
- ^ [2][dead link]
- ^ "C1orf123". Biogps.org. Retrieved 2015-02-25.
- ^ "Home - Geo - Ncbi". Ncbi.nlm.nih.gov. Retrieved 2013-09-22.
- ^ Välimäki S, Forsberg L, Farnebo LO, Larsson C (2002). "Distinct target regions for chromosome 1p deletions in parathyroid adenomas and carcinomas". Int. J. Oncol. 21 (4): 727–35. doi:10.3892/ijo.21.4.727. PMID 12239610.