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UBE2E1

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UBE2E1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
External IDsOMIM: 602916; MGI: 107411; HomoloGene: 84372; GeneCards: UBE2E1; OMA:UBE2E1 - orthologs
EC number2.3.2.24
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202476
NM_003341
NM_182666

NM_009455

RefSeq (protein)

NP_001189405
NP_003332
NP_872607
NP_003332.1

NP_033481

Location (UCSC)Chr 3: 23.81 – 23.89 MbChr 14: 4.14 – 4.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[5][6]

Function

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

Interactions

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UBE2E1 has been shown to interact with Ataxin 1[7] and NEDD4.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170142Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021774Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257.
  6. ^ a b "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".
  7. ^ Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907.
  8. ^ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. S2CID 1653536.
  9. ^ Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi:10.1074/jbc.C800030200. PMC 2276364. PMID 18287095.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin-conjugating enzyme E2 E1 (UBE2E1)