UBASH3A

UBASH3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRN
Identifiers
Aliases	UBASH3A, CLIP4, STS-2, TULA, TULA-1, ubiquitin associated and SH3 domain containing A
External IDs	OMIM: 605736; MGI: 1926074; HomoloGene: 56833; GeneCards: UBASH3A; OMA:UBASH3A - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,447,684 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,465,866 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; lymph node; ; testicle; ; thymus; ; spleen; ; appendix; ; gallbladder; ; rectum; ; tonsil;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; granulocyte; ; blood; ; embryo; ; yolk sac; ; parasympathetic nervous system; ; thyroid gland; ; pharynx; ; tongue;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus; nucleoplasm; Golgi apparatus;
Biological process	regulation of cytokine production; negative regulation of T cell receptor signaling pathway; negative regulation of signal transduction; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	53347
	328795
	ENSG00000160185
	ENSMUSG00000042345
	P57075
	Q3V3E1
	NM_001001895; NM_001243467; NM_018961
	NM_177823
	NP_001001895; NP_001230396; NP_061834
	NP_808491
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160185 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042345 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.
^ "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

Smirnova EV, Collingwood TS, Bisbal C, et al. (2008). "TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion". Virology. 372 (1): 10–23. doi:10.1016/j.virol.2007.10.012. PMID 18006034.
Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis". J. Biol. Chem. 282 (42): 30920–8. doi:10.1074/jbc.M706870200. PMID 17709377.
Bertelsen V, Breen K, Sandvig K, et al. (2007). "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis". Exp. Cell Res. 313 (8): 1696–709. doi:10.1016/j.yexcr.2007.02.017. hdl:10852/28097. PMID 17382318.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130. S2CID 1324257.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
Feshchenko EA, Smirnova EV, Swaminathan G, et al. (2004). "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin". Oncogene. 23 (27): 4690–706. doi:10.1038/sj.onc.1207627. PMID 15107835. S2CID 34698870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160185 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042345 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11281453-5] Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.

[entrez-6] "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

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References

Further reading