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Alternative splicing of the Drosophila Transformer gene product. Transformer (tra) is a family of genes which regulate sex determination in insects such as flies.[ 1] [ 2] P11596 Drosophila [ 3]
The tra-2 gene (P19018 sexual differentiation in female fruit flies, and for spermatogenesis in the males. It is not in the same protein family as tra , but instead works together with it in the splicing enhancer complex.[ 4] [ 5]
^ Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF) . Current Opinion in Genetics & Development . 20 (4): 376–383. doi :10.1016/j.gde.2010.05.001 . hdl :11370/2174764d-bd1b-4e1f-b142-90aced0c3e55 PMID 20570131 . S2CID 205003182 . ^ An X, Ota T, O'Neil MT, Steinmann-Zwicky M, Yamamoto D, et al. "tra - transformer" . Gene Review . Nature Genetics. Archived from the original on 5 August 2021. Retrieved 7 December 2017 . ^ Rideout EJ, Narsaiya MS, Grewal SS (December 2015). "The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size" . PLOS Genetics . 11 (12): e1005683. doi :10.1371/journal.pgen.1005683 PMC 4692505 PMID 26710087 . ^ Amrein H, Gorman M, Nöthiger R (December 1988). "The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein". Cell . 55 (6): 1025–1035. doi :10.1016/0092-8674(88)90247-4 . PMID 3144434 . S2CID 21183373 . ^ "Transformer-2 sex-determining protein" . UniProt. Retrieved 7 December 2017 .
