TUBE1

TUBE1
Identifiers
Aliases	TUBE1, TUBE, dJ142L7.2, tubulin epsilon 1
External IDs	OMIM: 607345; MGI: 1919174; HomoloGene: 17762; GeneCards: TUBE1; OMA:TUBE1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	112,087,529 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	39,152,542 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; oocyte; ; secondary oocyte; ; pancreatic epithelial cell; ; Achilles tendon; ; body of uterus; ; right lobe of liver; ; cardiac muscle tissue of right atrium; ; right auricle; ; C1 segment;
	Top expressed in
	thymus; ; secondary oocyte; ; medullary collecting duct; ; hand; ; neural layer of retina; ; primary oocyte; ; primitive streak; ; zygote; ; renal corpuscle; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; structural constituent of cytoskeleton; GTPase activity;
Cellular component	cytoplasm; microtubule; pericentriolar material; cytoskeleton; microtubule organizing center;
Biological process	centrosome cycle; microtubule-based process; microtubule cytoskeleton organization; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	51175
	71924
	ENSG00000074935
	ENSMUSG00000019845
	Q9UJT0
	Q9D6T1
	NM_016262
	NM_028006
	NP_057346
	NP_082282
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin, epsilon 1 is a protein in humans that is encoded by the TUBE1 gene.^[5] This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074935 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019845 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tubulin, epsilon 1".

Chang P, Giddings TH, Winey M, Stearns T (January 2003). "Epsilon-tubulin is required for centriole duplication and microtubule organization". Nature Cell Biology. 5 (1): 71–6. doi:10.1038/ncb900. PMID 12510196. S2CID 1318660.
Zanic M, Stear JH, Hyman AA, Howard J (October 2009). May RC (ed.). "EB1 recognizes the nucleotide state of tubulin in the microtubule lattice". PLOS ONE. 4 (10): e7585. Bibcode:2009PLoSO...4.7585Z. doi:10.1371/journal.pone.0007585. PMC 2761489. PMID 19851462.
Chang P, Stearns T (January 2000). "Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology. 2 (1): 30–5. doi:10.1038/71350. PMID 10620804. S2CID 23500269.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074935 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019845 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tubulin, epsilon 1".

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References

Further reading