TTLL1

TTLL1
Identifiers
Aliases	TTLL1, C22orf7, HS323M22B, tubulin tyrosine ligase like 1, TTL family tubulin polyglutamylase complex subunit L1, TPGS3
External IDs	OMIM: 608955; MGI: 2443047; HomoloGene: 8174; GeneCards: TTLL1; OMA:TTLL1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	43,089,419 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	83,395,094 bp
RNA expression pattern
	Top expressed in
	gonad; ; ganglionic eminence; ; bronchial epithelial cell; ; ventricular zone; ; testicle; ; mucosa of paranasal sinus; ; prefrontal cortex; ; frontal pole; ; right uterine tube; ; oocyte;
	Top expressed in
	myocardium of ventricle; ; interventricular septum; ; right ventricle; ; Rostral migratory stream; ; cardiac muscles; ; facial motor nucleus; ; anterior horn of spinal cord; ; dorsomedial hypothalamic nucleus; ; median eminence; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ligase activity; ATP binding; tubulin-glutamic acid ligase activity;
Cellular component	cytoplasm; microtubule; cytoskeleton; extracellular region;
Biological process	epithelial cilium movement involved in extracellular fluid movement; protein polyglutamylation; axoneme assembly; sperm axoneme assembly;
	Sources:Amigo / QuickGO
Orthologs
	25809
	319953
	ENSG00000100271
	ENSMUSG00000022442
	O95922
	Q91V51
	NM_001008572; NM_012263
	NM_178869; NM_001357953
	NP_036395
	NP_849200; NP_001344882
	Wikidata
View/Edit Human	View/Edit Mouse

Probable tubulin polyglutamylase TTLL1 is an enzyme that in humans is encoded by the TTLL1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100271 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022442 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ Trichet V, Ruault M, Roizes G, De Sario A (Dec 2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–17. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.
^ "Entrez Gene: TTLL1 tubulin tyrosine ligase-like family, member 1".

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Janke C, Rogowski K, Wloga D, et al. (2005). "Tubulin polyglutamylase enzymes are members of the TTL domain protein family". Science. 308 (5729): 1758–62. Bibcode:2005Sci...308.1758J. doi:10.1126/science.1113010. PMID 15890843. S2CID 25798588.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100271 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022442 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[pmid11054573-6] Trichet V, Ruault M, Roizes G, De Sario A (Dec 2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–17. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.

[entrez-7] "Entrez Gene: TTLL1 tubulin tyrosine ligase-like family, member 1".

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References

Further reading