Transmembrane protein 151b

TMEM151B
Identifiers
Aliases	TMEM151B, C6orf137, TMEM193, bA444E17.5, transmembrane protein 151B
External IDs	MGI: 2685169; HomoloGene: 19365; GeneCards: TMEM151B; OMA:TMEM151B - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	44,307,506 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	45,860,603 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; right hemisphere of cerebellum; ; frontal pole; ; cerebellar vermis; ; Brodmann area 10; ; right frontal lobe; ; middle temporal gyrus; ; orbitofrontal cortex; ; Brodmann area 46; ; superior frontal gyrus;
	Top expressed in
	primary visual cortex; ; cerebellar cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; ganglionic eminence; ; barrel cortex; ; prefrontal cortex; ; central gray substance of midbrain; ; lobe of cerebellum; ; hippocampus proper;
	More reference expression data
	n/a
Orthologs
	441151
	210573
	ENSG00000178233
	ENSMUSG00000096847
	Q8IW70
	Q68FE7
	NM_001137560; NM_001039704
	NM_001013749
	NP_001131032
	NP_001013771
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene.^[5]

Nomenclature

The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.^[6]

Gene

The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs.^[7] It is a complex locus that contains both TMEM151B and SPATS1.^[8] TMEM151B has one paralog: TMEM151A.^[9]

Transcript

The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp.^[7]

Visualization of the TMEM151B gene. The green lines above the diagram show other promotors within the gene.

Protein

The protein has a length of 566 amino acids and contains two transmembrane domains.^[6] According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72.^[11]^[6] The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor.^[12]

Expression

RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes.^[14] NCBI geo profiles similarly show localization to the brain tissues.^[15] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas.^[13]

Protein interactions

The TMEM151B protein interacts with one other protein according to BioGRID.^[16]

SREBF2- a transcription factor precursor which is imbedded in the endoplasmic reticulum membrane; activates genes involved with cholesterol biosynthesis.^[17]

Homology and evolution

The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B.^[9]^[18] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c.^[9]^[19]

Research

Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer.^[20] It was also found to be up-regulated in post-menopausal breast cancer.^[21]^[22] A SNP found within TMEM151B is associated with the development of lean muscle.^[23]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178233 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000096847 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Transmembrane protein 151B".
^ ^a ^b ^c "transmembrane protein 151B [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
^ ^a ^b "Homo sapiens transmembrane protein 151B (TMEM151B), mRNA - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
^ "AceView: Gene:TMEM151BandSPATS1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2021-10-04.
^ ^a ^b ^c ^d "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
^ "Protter - interactive protein feature visualization". wlab.ethz.ch. Retrieved 2022-01-13.
^ "ExPASy - Compute pI/Mw tool". web.expasy.org. Retrieved 2022-01-13.
^ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
^ ^a ^b "ISH Data :: Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2022-01-13.
^ "TMEM151B transmembrane protein 151B [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
^ "GDS596 / 213678_at". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
^ "TMEM151B (RP11-444E17.5) Result Summary | BioGRID". thebiogrid.org. Retrieved 2022-01-13.
^ "SREBF2 Gene - GeneCards | SRBP2 Protein | SRBP2 Antibody". www.genecards.org. Retrieved 2022-01-13.
^ "Clustal Omega < Multiple Sequence Alignment < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
^ "TimeTree :: The Timescale of Life". www.timetree.org. Retrieved 2022-01-13.
^ Liu J, Li H, Shen S, Sun L, Yuan Y, Xing C (2018). "Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer". Journal of Cancer. 9 (10): 1754–1764. doi:10.7150/jca.24569. PMC 5968763. PMID 29805701.
^ Carter JM, Nair AA, Davila JI, Heinzen EP, Hoskin TL, Winham SJ, et al. (2019-02-15). "Abstract P3-08-10: A unique coding and non-coding benign breast transcriptome in post-menopausal ER+ breast cancer". Poster Session Abstracts. 79 (4_Supplement). American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-p3-08-10. S2CID 164377723.
^ Qian D, Zheng Q, Wu D, Ye B, Qian Y, Zhou T, et al. (2021-05-13). "Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer". Frontiers in Oncology. 11: 670138. doi:10.3389/fonc.2021.670138. PMC 8158160. PMID 34055638.
^ Pei YF, Hu WZ, Yang XL, Wei XT, Feng GJ, Zhang H, et al. (November 2019). "Two functional variants at 6p21.1 were associated with lean mass". Skeletal Muscle. 9 (1): 28. doi:10.1186/s13395-019-0212-3. PMC 6874818. PMID 31757224.