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TBCD

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TBCD
Identifiers
AliasesTBCD, SSD-1, tfcD, tubulin folding cofactor D, PEBAT
External IDsOMIM: 604649; MGI: 1919686; HomoloGene: 4368; GeneCards: TBCD; OMA:TBCD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033052
NM_005993

NM_029878

RefSeq (protein)

NP_005984

NP_084154

Location (UCSC)Chr 17: 82.75 – 82.95 MbChr 11: 121.34 – 121.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.[5]

Function

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Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.[5]

Interactions

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TBCD has been shown to interact with ARL2.[6][7]

References

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  1. ^ a b c ENSG00000141556 GRCh38: Ensembl release 89: ENSG00000278759, ENSG00000141556Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039230Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TBCD tubulin folding cofactor D".
  6. ^ Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.
  7. ^ Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. PMC 2174823. PMID 10831612.

Further reading

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