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Mammalian protein found in humans
Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein belonging to a family of keratan sulfate proteoglycans , located on the synaptic vesicles of mammalian neuronal and endocrine cells. It's encoded by the SV2A gene .[ 5] [ 6] [ 7]
SV2A is the most widely expressed isoform of the SV2 family (which also includes the SV2B and SV2C proteins) found in all brain regions.[ 8] [ 8]
The SV2A protein is a target of the anti-epileptic drugs (anticonvulsants ) levetiracetam and brivaracetam [ 9] [ 10]
SV2A is differentially expressed in both inhibitory GABA ergic and excitatory glutamatergic terminals[ 11] [ 12] [ 13] GABA than glutamate [ 14] [ 15]
Several PET radiotracers targeting SV2A have been developed, allowing for measuring SV2A density in-vivo: [11C]LEV, [11C]UCB -A, [11C]-UCB-H, [18F]UCB-J, [18F]Syn-VesT-1, [18F]Syn-VesT-2, and [18F]SDM-16. SV2A density has been used as a proxy for measuring in vivo synaptic density.[ 16] [ 17] [ 18] [ 19]
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Journal of Neuroscience . 14 (9): 5223– 5235. doi :10.1523/JNEUROSCI.14-09-05223.1994 . ISSN 0270-6474 . PMC 6577109 PMID 8083732 . ^ Mendoza-Torreblanca, Julieta G.; García-Cruz, M. Edna; Sánchez-Cruz, Itzel; Gomez-Gonzalez, Beatriz; Juárez-Méndez, Sergio; Gómez-Lira, Gisela (November 2019). "Analysis of Differential Expression of Synaptic Vesicle Protein 2A in the Adult Rat Brain" . Neuroscience . 419 : 108– 120. doi :10.1016/j.neuroscience.2019.09.004 . PMID 31520710 . ^ Vanoye-Carlo, América; Gómez-Lira, Gisela (July 2019). "Differential expression of SV2A in hippocampal glutamatergic and GABAergic terminals during postnatal development" . Brain Research . 1715 : 73– 83. doi :10.1016/j.brainres.2019.03.021 . 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Overview of all the structural information available in the PDB for UniProt : Q7L0J3 PDBe-KB . 
