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Xiaoliang Sunney Xie

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For the singer, see Sunny Xie.
Xiaoliang Sunney Xie
Born (1962-06-24) June 24, 1962 (age 62)
Beijing, China
EducationBSc in chemistry from Peking University
PhD in Physical Chemistry from UC San Diego
Known forSingle Molecule Enzymology,
Coherent Raman Imaging,
Single Cell Genomics
AwardsAlbany Prize in Medicine and Biomedical Research 2015,
Peter Debye Award in Physical Chemistry 2015,
Ellis R. Lippincott Award 2013,
Biophysical Society Founders Award 2012
NAS 2011
NAM 2016
CAS 2017
Scientific career
FieldsBiophysical Chemistry,
Optical Imaging,
Genomics
InstitutionsHarvard University
Peking University
Doctoral advisorJohn Douglas Simon[1]
In this Chinese name, the family name is Xie.

Xiaoliang Sunney Xie (Chinese: 谢晓亮; born 24 June 1962) is a Chinese biophysicist well known for his contributions to the fields of single-molecule biophysical chemistry, coherent Raman Imaging and single-molecule genomics. In 2023, Xie renounced his U.S. citizenship in order to reclaim his Chinese citizenship.[2]

Early life

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Xie was born in Beijing in 1962 with ancestral roots in Hepu County, Guangxi. He received his B.Sc. in chemistry from Peking University in 1984, and his Ph.D. in physical chemistry in 1990 from University of California at San Diego. After a brief postdoctoral appointment at University of Chicago, he joined Pacific Northwest National Laboratory, where he rose from senior research scientist to chief scientist. In 1998, he became the first tenured professor recruited by Harvard University among Chinese scholars who came to the United States since Chinese economic reform.

Research

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He had been the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard University until 2018, when he became the Lee Shau-kee Professor of Peking University. He was the Director of Biomedical Pioneering Innovation Center (BIOPIC) in 2010-2021, and the Director of Beijing Advanced Innovation Center for Genomics (ICG) in 2016-2021, both at Peking University.

As a pioneer of single-molecule biophysical chemistry, Coherent Raman scattering microscopy, and single-cell genomics, he made major contributions to the emergence of these fields. Furthermore, he has made significant advances on medical applications of label-free optical imaging and single-cell genomics. In particular, his inventions in single-cell genomics have been used in in vitro fertilization benefited thousands of families by avoiding the transmission of monogenic diseases to their newborns.

More than fifty of his students and post-doctorates have become professors at major universities around the world, and two are co-founders of start-up companies. Professor Xie’s current research interests include the following scientific, technological, and medical areas:

Honors and awards

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Selected Literature

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COVID-19 Research

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  • Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong; Xie, Xiaoliang Sunney; Xiao, Junyu (25 August 2021). "Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants". Cell Research. 31 (10). Springer Science and Business Media LLC: 1130–1133. doi:10.1038/s41422-021-00555-0. ISSN 1001-0602. PMC 8385480. PMID 34433900.
  • Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yisimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; An, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney (23 December 2021). "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies". Nature. 602 (7898). Springer Science and Business Media LLC: 657–663. doi:10.1038/s41586-021-04385-3. ISSN 0028-0836. PMC 8866119. PMID 35016194.
  • Cao, Yunlong; Yisimayi, Ayijiang; Bai, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Yuan, Tianjiao; An, Ran; Wang, Jing; Xiao, Tianhe; Du, Shuo; Ma, Wenping; Song, Liyang; Li, Yongzheng; Li, Xiang; Song, Weiliang; Wu, Jiajing; Liu, Shuo; Li, Xuemei; Zhang, Yonghong; Su, Bin; Guo, Xianghua; Wei, Yangyang; Gao, Chuanping; Zhang, Nana; Zhang, Yifei; Dou, Yang; Xu, Xiaoyu; Shi, Rui; Lu, Bai; Jin, Ronghua; Ma, Yingmin; Qin, Chengfeng; Wang, Youchun; Feng, Yingmei; Xiao, Junyu; Xie, Xiaoliang Sunney (21 May 2021). "Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines". Cell Research. 31 (7). Springer Science and Business Media LLC: 732–741. doi:10.1038/s41422-021-00514-9. ISSN 1001-0602. PMC 8138844. PMID 34021265.
  • Du, Shuo; Cao, Yunlong; Zhu, Qinyu; Yu, Pin; Qi, Feifei; Wang, Guopeng; Du, Xiaoxia; Bao, Linlin; Deng, Wei; Zhu, Hua; Liu, Jiangning; Nie, Jianhui; Zheng, Yinghui; Liang, Haoyu; Liu, Ruixue; Gong, Shuran; Xu, Hua; Yisimayi, Ayijiang; Lv, Qi; Wang, Bo; He, Runsheng; Han, Yunlin; Zhao, Wenjie; Bai, Yali; Qu, Yajin; Gao, Xiang; Ji, Chenggong; Wang, Qisheng; Gao, Ning; Huang, Weijin; Wang, Youchun; Xie, X. Sunney; Su, Xiao-dong; Xiao, Junyu; Qin, Chuan (2020). "Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy". Cell. 183 (4). Elsevier BV: 1013–1023.e13. doi:10.1016/j.cell.2020.09.035. ISSN 0092-8674. PMC 7489885. PMID 32970990.
  • Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; He, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Tan, Yafang; Song, Liyang; Wang, Guopeng; Du, Xiaoxia; Gao, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiao-dong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney (2020). "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells". Cell. 182 (1). Elsevier BV: 73–84.e16. doi:10.1016/j.cell.2020.05.025. ISSN 0092-8674. PMC 7231725. PMID 32425270.

Single-Cell Genomics

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Gene Expression and Regulation

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Single Molecule Enzymology

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Coherent Raman Imaging

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Single Molecule Imaging

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See also

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References

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  1. ^ "About Professor Xie". Archived from the original on 2018-10-10. Retrieved 2018-10-10.
  2. ^ "Xie Xiaoliang is latest Chinese scientist to give up US citizenship". South China Morning Post. 9 June 2023. Retrieved 20 June 2023.
  3. ^ "PKU Professor Xiaoliang Sunney Xie awarded Qiu Shi Outstanding Scientist Award of 2017". Peking University. Archived from the original on 2018-10-10. Retrieved 2018-10-10.
  4. ^ "关于公布2017年中国科学院院士增选当选院士名单的公告" (in Chinese). Chinese Academy of Sciences. 2017-11-28. Archived from the original on 2019-11-23. Retrieved 2019-11-22.
  5. ^ "National Academy of Medicine Elects 79 New Members". Archived from the original on 2019-10-18. Retrieved 2016-11-02.
  6. ^ "Albany Medical Center Prize". Archived from the original on 2015-04-23. Retrieved 2015-04-20.
  7. ^ "Peter Debye Award". Archived from the original on 2017-08-25. Retrieved 2015-04-20.
  8. ^ "NIH Director's Pioneer Award 2013". Archived from the original on 2014-02-21. Retrieved 2013-11-14.
  9. ^ "Ellis R. Lippincott Award". Archived from the original on 2016-10-31. Retrieved 2016-11-02.
  10. ^ "Berthold Leibinger Zukunftspreis". Archived from the original on 2016-10-27. Retrieved 2015-04-20.
  11. ^ "Biography of Xie from the Website of the Willis E. Lamb Award (displayed June 4, 2008)". Archived from the original on August 20, 2008. Retrieved June 4, 2008.
  12. ^ "NIH Director's Pioneer Award 2004". Archived from the original on 2016-12-20. Retrieved 2015-04-20.
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