Sodium fluoroacetate: Difference between revisions
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In clinical cases, use of [[muscle relaxant]]s, [[anti-convulsant]]s, [[mechanical ventilation]] and other supportive measures may all be required. Few animals or people have been treated successfully after significant sodium fluoroacetate ingestions. |
In clinical cases, use of [[muscle relaxant]]s, [[anti-convulsant]]s, [[mechanical ventilation]] and other supportive measures may all be required. Few animals or people have been treated successfully after significant sodium fluoroacetate ingestions. |
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==Uses== |
==Uses== |
Revision as of 23:14, 24 June 2008
Sodium fluoroacetate (also known as sodium monofluoroacetate, compound 1080 or 1080) is a potent metabolic poison that occurs naturally as an anti-herbivore metabolite in various plants. It works by interfering with the citric acid cycle, and is used primarily to control mammalian pests, including invasive species. The existence of this chemical was first noted in the Second World War.
History
Sodium fluoroacetate was discovered by German military chemists in World War II. The chemical was highly potent — but it was difficult to deliver, requiring ingestion or injection for optimal effect.[citation needed] As such, it was largely overlooked until it was independently rediscovered by American chemists researching pesticides.[1] The name "1080" refers to the catalogue number of the poison, which became its brand name.[2]
Natural occurrence
Sodium fluoroacetate occurs naturally in at least 40 plants in Australia, Brazil and Africa. It was first identified as the poison of poison leaf Dichapetalum cymosum by Marais in 1944,[3][4] although it had been reported as early as 1904 that colonists in Sierra Leone used extracts of Chailletia toxicaria which also contains fluoroacetic acid or its salts to poison rats.[5][6] It is believed that the compound is even present in tea leaves in tiny amounts.[7] The Australian pea family Gastrolobium (“poison peas”), have sodium fluoroacetate in the leaf tips and seeds. This forces livestock farmers in Western Australia to hand-weed out all the plants from their paddocks. It also means that some Western Australian herbivores have, by natural selection, developed partial immunity to the effects of fluoroacetate; this has been used for an advantage in DEC’s wildlife conservation project named Western Shield.
Toxicity
Fluoroacetate is highly toxic to mammals and insects.[2] The oral dose of fluoroacetate sufficient to be lethal in humans is 2–10 mg/kg.[8]
Species have different susceptibility to sodium fluoroacetate due to metabolic differences. The New Zealand Food Authority established lethal doses for a number of species.[9] Dogs, cats and pigs appear to be the species most susceptable to poisoning.[9]
Mechanism of action
Fluoroacetate is similar to acetate, which has a pivotal role in cellular metabolism. Fluoroacetate disrupts the citric acid cycle (also known as the Krebs cycle) by combining with coenzyme A to form fluoroacetyl CoA. This is then substituted for acetyl CoA in the citric acid cycle and reacts with citrate synthase to produce fluorocitrate. A metabolite of fluorocitrate binds very tightly to aconitase, thereby halting the citric acid cycle. This results in an accumulation of citrate in the blood which deprives cells of energy.[2]
Symptoms
In humans the symptoms of poisoning normally appear between 30 minutes and three hours after exposure. Initial symptoms typically include nausea, vomiting and abdominal pain; sweating, confusion and agitation follow. In significant poisoning cardiac abnormalities including tachycardia or bradycardia, hypotension and ECG changes develop. Neurological effects include muscle twitching and seizures; Consciousness becomes progressively impaired after a few hours leading to coma. Death is generally due to Ventricular arrhythmias, progressive hypotension unresponsive to treatment, and secondary lung infections.[2]
Symptoms in domestic animals vary: dogs tend to show nervous system signs such as convulsions and uncontrollable running, whilst large herbivores such as cattle and sheep more predominantly show cardiac signs.[citation needed]
Sub-lethal doses of sodium fluoroacetate may cause damage to tissues with high energy needs — in particular, the brain, gonads, heart, lungs and fetus. Sub-lethal doses are typically completely metabolised and excreted within four days.[citation needed]
Treatment
Because of the biochemical interference in the TCA or Krebs Cycle, sodium fluoroacetate poisoning is very difficult to treat, as once clinical symptoms are shown, the Krebs Cycle has shut down. There is no known effective antidote. Research in monkeys has shown that the use of glyceryl monoacetate can prevent problems if given after ingestion of sodium fluoroacetate, and this has been done in domestic animals with some positive results. The theory of using glyceryl monoacetate is that it will supply acetate ions to allow continuation of the cellular respiration process which the sodium fluoroacetate has disrupted.
In clinical cases, use of muscle relaxants, anti-convulsants, mechanical ventilation and other supportive measures may all be required. Few animals or people have been treated successfully after significant sodium fluoroacetate ingestions.
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Uses
![](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b9/Brushtail_possum.jpg/180px-Brushtail_possum.jpg)
Sodium fluoroacetate is used as a rodenticide. Farmers and graziers use the poison to protect pastures and crops from various herbivorous mammals. It is used in New Zealand to control the Common Brushtail Possum [1] , while in the United States it is used to kill coyotes. Other countries using 1080 include Australia, Mexico and Israel.[2]
Western Shield is a recent project to boost populations of endangered mammals in south-west Australia. The project is to drop Sodium fluoroacetate baited meat from helicopters or light aircraft to kill predators. Wild dogs and foxes will readily eat the baited meat. Cats pose a greater difficulty as cats aren’t interested in already dead animals. Recently a pilot tried putting small sound generators inside the baits with significant positive results.[citation needed] However, an Australian RSPCA commissioned study criticized 1080 calling it an inhumane killer.[10]
New Zealand 1080 application
![](http://upload.wikimedia.org/wikipedia/commons/thumb/f/fc/1080PoisonWarning_gobeirne.jpg/180px-1080PoisonWarning_gobeirne.jpg)
Worldwide, New Zealand is the largest user of sodium fluoroacetate. The first trials were carried out in New Zealand in 1954, and by 1957 its use had become widespread. 1080 baits are used through ground based and aerial application to control possums (an animal pest introduced from Australia) and other introduced mammalian pests.[8] New Zealand's unique fauna and flora is endangered by the rapid spread of possums, stoats and rats.[11] As the Possum is from the eastern states of Australia and is a mainly arboreal forager, it has never developed a resistance to sodium fluoroacetate.[citation needed]
While New Zealand's Department of Conservation Doc and the Animal Health Board [2] favors the effectiveness of aerial 1080 application,[12] critics of the application of 1080 claim: “ agencies increasingly use large scale aerial applications to cut costs". A positive side effect of aerial poisoning is a temporary drop in rat numbers, but they recover due to the niche created by low possum numbers. New Zealand's Environment Risk Management Authority ERMA released in August 2007 its latest review of the matter. The review gives new guidelines for the use of 1080 in New Zealand and concludes that the beneficial effects of pest eradication outweigh the risks.[13]
Footnotes
![]() | This article has an unclear citation style. (September 2007) |
- ^ Kalmbach ER (1945). "Ten-Eighty, a War-Produced Rodenticide". Science. 102 (2644): 232–3. doi:10.1126/science.102.2644.232.
- ^ a b c d e Proudfoot AT, Bradberry SM, Vale JA (2006). "Sodium fluoroacetate poisoning". Toxicol Rev. 25 (4): 213–9. doi:10.2165/00139709-200625040-00002. PMID 17288493.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Marais JCS (1943). "The isolation of the toxic principle "K cymonate" from "Gifblaar", Dichapetalum cymosum". Onderstepoort Jour. Vet. Sci. Animal Ind. 18: 203.
- ^ Marais JCS (1944). "Monofluoroacetic acid, the toxic principle of "gifblaar" Dichapetalum cymosum". Onderstepoort Jour. Vet. Sci. Animal Ind. 20: 67.
- ^ Renner (1904). "Chemical and Physiological Examination of the Fruit of Chailletia Toxicaria". Jour African Soc.: 109.
- ^ Power FB, Tutin F (1906). "C hemical and Physiological Examination of the Fruit of Chailletia Toxicaria". J. Am. Chem. Soc. 28: 1170. doi:10.1021/ja01975a007.
- ^ Vartiainen T, Kauranen P (1984). "The determination of traces of fluoroacetic acid by extractive alkylation, pentafluorobenzylation and capillary gas chromatography-mass spectrometry". Anal Chim Acta. 157 (1): 91–7. doi:10.1016/S0003-2670(00)83609-0.
- ^ a b Beasley, Michael (August 2002). "Guidelines for the safe use of sodium fluoroacetate (1080)" (PDF). New Zealand Occupational Safety & Health Service. Retrieved 2007-12-17.
- ^ a b "Controlled Pesticides: Sodium Fluoroacetate (1080) in Pest Control" (PDF). Agricultural Compounds and Veterinary Medicines Group. Retrieved 2007-12-17.
- ^ Speechley, Jane (15 November 2007). "1080 is not a humane poison: International journal publishes RSPCA paper". RSPCA. Retrieved 2007-12-17.
{{cite web}}
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(help) - ^ "Possum Control - Facts About 1080". New Zealand Department of Conservation. 2001. Retrieved 2007-12-17.
- ^ Green, Wren (July 2004). "The use of 1080 for pest control" (PDF). New Zealand Department of Conservation. Retrieved 2007-12-17.
- ^ "Environmental Risk Management Authority Decision on 1080" (PDF). ERMA New Zealand. August 2007. Retrieved 2007-12-17.
References
- Klingensmith CW (1945). "The Natural Occurrence of Fluoroacetic Acid, the Acid of the New Rodenticide 1080". Science. 102: 622–623. doi:10.1126/science.102.2659.622. PMID 17818201.
External links
- New Zealand Department of Conservation Facts about the use of 1080
- Western Australian Department of Environment and Conservation report on their Western Shield project.
- Press release on the ban of 1080 use in Tasmanian forests
- Notes on 1080 use for controlling predators in Idaho
- Exposure and Risk Assessment (1080) Risk to human health from 1080 pest control application, ERMA New Zealand
- [3] New Zealand Animal Health Board