Scoliosis

Scoliosis
Specialty	Orthopedic surgery

A coronal X-ray of a person with thoracic dextroscoliosis and lumbar levoscoliosis. The X-ray is projected such that the right side of the subject is on the right side of the image, i.e. the subject is viewed from the rear. This projection is typically used by surgeons as it is how surgeons see their patients when they are on the operating table.

Scoliosis is a medical condition in which a person's spine is curved from side to side or front to back, and may also be rotated. On an x-ray, the spine of an individual with a typical scoliosis may look more like an "S" or a "C" than a straight line. It is typically classified as congenital (caused by vertebral anomalies present at birth), idiopathic (sub-classified as infantile, juvenile, adolescent, or adult according to when onset occurred) or as having developed as a secondary symptom of another condition, such as cerebral palsy or spinal muscular atrophy.

Terminology

Dextroscoliosis is a scoliosis with the convexity on the right side.

Levoscoliosis is a scoliosis with the convexity on the left side.

Medoscoliosis is a scoliosis with the convexity in the middle.

Cause

In the case of the most common form of scoliosis, Adolescent Idiopathic Scoliosis, there is a clear Mendelian inheritance but with incomplete penetrance. Various causes have been implicated, but none has consensus among scientists as the cause of scoliosis. Scoliosis is more often diagnosed in females and is often seen in patients with cerebral palsy or spina bifida, although this form of scoliosis is different from that seen in children without these conditions. In some cases, scoliosis exists at birth due to a congenital vertebral anomaly. Occasionally, development of scoliosis during adolescence is due to an underlying anomaly such as a tethered spinal cord, but most often the cause is unknown or idiopathic. Contrary to popular belief, research has shown that scoliosis can also be caused by muscular reaction to trauma .. Scoliosis often presents itself, or worsens, during the adolescence growth spurt.

In April 2007, researchers at Texas Scottish Rite Hospital for Children identified the first gene associated with idiopathic scoliosis, CHD7. The medical breakthrough was the result of a 10-year study and is outlined in the May 2007 issue of the American Journal of Human Genetics.

In March 2007, researchers found that Scoliosis can be transmitted amongst humans orally. The disease can also be transmitted if one touches a certain Laura Smith's body at any particular point. While on a trip to Las Vegas in 2008, Laura Smith infected nearly 1.3 million people, along with 864 animals. The city of Las Vegas had to be quarantined and disinfected. Experts say the city will never be the same. The effects of Ms. Smith will haunt the city forever.

Prevalence

Scoliotic curves greater than 10° affect 2-3% of the population of the United States. The prevalence of curves less than 20° is about equal in males and females. Curves greater than 20° affect about 1 in 2500 people. Curves convex to the right are more common than those to the left, and single or 'C' curves are slightly more common than double or 'S' curve patterns. Males are more likely to have infantile or juvenile scoliosis, but there is a high female predominance of adolescent scoliosis.

Symptoms

Pain is common in adulthood, especially if left untreated. One of the major complaints from parents and patients is cosmetic deformity.

The symptoms of scoliosis can include:

• Uneven musculature on one side of the spine
• A rib "hump" and/or a prominent shoulder blade, caused by rotation of the ribcage in thoracic scoliosis
• Uneven hip and shoulder levels
• Asymmetric size or location of breast in females
• Unequal distance between arms and body
• Clothes that do not "hang right", ie. with uneven hemlines
• Slow nerve action (in some cases)

Associated conditions

Scoliosis is sometimes associated with other conditions such as cerebral palsy, spinal muscular atrophy, familial dysautonomia, CHARGE syndrome, Friedreich's ataxia, Spina bifidas, Marfan's syndrome, neurofibromatosis, connective tissue disorders, and craniospinal axis disorders (e.g., syringomyelia, Arnold-Chiari malformation).

However, the majority of people with adolescent scoliosis have no pain or other abnormalities.

Investigation

Cobb angle measurement of a dextroscoliosis.

Patients who initially present with scoliosis are examined to determine if there is an underlying cause of the deformity. During a physical examination, the following is assessed:

• Skin for café au lait spots indicative of neurofibromatosis
• The feet for cavovarus deformity
• Abdominal reflexes
• Muscle tone for spasticity

During the exam, the patient is asked to bend forward (Adam's Bend Test). If a hump is noted, then scoliosis is a possibility and the patient should be sent for an x-ray to confirm the diagnosis. The patient's gait is assessed, and there is an exam for signs of other abnormalities (e.g., Spina bifida as evidenced by a dimple, hairy patch, lipoma, or hemangioma). A thorough neurological examination is also performed.

Many doctors when suspecting scoliosis will exclaim "scolie and AP-Lateral", which are two types of X-ray. The scolie is pictured above, a scolie is an X-ray taken from the rear. An AP-Lateral is taken from the side but the xray machine is programmed only to show the spine with high definition.

Full-length standing spine X rays are the standard method for evaluating the severity and progression of the scoliosis, and whether it is congenital or idiopathic in nature. In growing individuals, serial radiographs are obtained at 3-12 month intervals to follow curve progression. In some instances, MRI investigation is warranted.

The standard method for assessing the curvature quantitatively is measurement of the Cobb angle, which is the angle between two lines, drawn perpendicular to the upper endplate of the uppermost vertebrae involved and the lower endplate of the lowest vertebrae involved. For patients who have two curves, Cobb angles are followed for both curves. In some patients, lateral bending xrays are obtained to assess the flexibility of the curves or the primary and compensatory curves.

Mass-screening for scoliosis using posture photos

It has been suggested that entire populations be examined, for early detection. For example, in the 1940s, American psychologist William Sheldon proposed mandatory physical examinations that included nude photographs of each person being examined. One purpose of these photographs was the detection of rickets, scoliosis, and lordosis. His approach was implemented at a number of ivy league schools in which all freshmen were examined ((Ivy League nude posture photos). A similar program was implemented in Boston's prison system.

Prognosis

The prognosis of scoliosis depends on the likelihood of progression. The general rules of progression are that larger curves carry a higher risk of progression than smaller curves, and that thoracic and double primary curves carry a higher risk of progression than single lumbar or thoracolumbar curves. In addition, patients who have not yet reached skeletal maturity have a higher likelihood of progression.

Management

The traditional medical management of scoliosis is complex and is determined by the severity of the curvature, skeletal maturity, which together help predict the likelihood of progression.

The conventional options are, in order:

1. Observation
2. Bracing - for example the Milwaukee brace
3. Surgery

Bracing is only done when the patient has bone growth remaining, and is generally implemented in order to hold the curve and prevent it from progressing to the point where surgery is necessary. Bracing involves fitting the patient with a device that covers the torso and in some cases it extends to the neck. The most commonly used brace is a TLSO, a corset-like appliance that fits from armpits to hips and is custom-made from plastic. It is usually worn 23 hours a day and applies pressure on the curves in the spine. Bracing is only mildly effective as compliance is typically low, although some of the newer braces (such as the Charleston back brace) are touting better compliance rates and outcomes. Typically braces are only used for idiopathic curves that are not grave enough to warrant surgery, but they may also be used to prevent the progression of more severe curves in young children, in order to buy the child time to grow before performing surgery which would prevent further growth in the part of the spine affected.

In infantile, and sometimes juvenile scoliosis, a body cast or plaster jacket may be used instead of a brace. It has been proven possible to permanently correct some cases of infantile idiopathic scoliosis by using a series of plaster body casts applied under corrective traction, which help to "mould" the infant's soft bones and work with their infantile growth spurts. This method was pioneered by UK scoliosis specialist Min Mehta.

Chiropractic and physical therapy have some degree of anecdotal success in treating scoliosis that is primarily neuromuscular in nature, however non-surgical approaches will not address severe bone deformities associated with many cases of scoliosis. Chiropractors utilize joint mobilization techniques and therapeutic exercise to increase a scoliosis patient's flexibility and strength, theorizing that this better enables the brace to influence the curvature of the spine. Electronic Muscle Stimulation (EMS) is another therapeutic modality commonly utilized by chiropractors and physical therapists to reduce muscle spasms and strengthen atrophied muscles.

There is limited published scientific research to evaluate the efficiency of treatment programs that include a combination of bracing along with physical therapy. While much debate remains in the scientific community about whether or not chiropractic and physical therapy can influence scoliotic curvature, there may well be palliative benefit from them in scoliosis patients who experience back pain either directly as a result of their deformity or indirectly from wearing an uncomfortable brace for the vast majority of the day.

A non-invasive treatment for idiopathic scoliosis used successfully in Europe since the 1920s. Originally developed in Germany by scoliosis sufferer Katharina Schroth, this method is now taught to scoliosis patients in clinics specifically devoted to Schroth therapy in Germany, Spain, England, and, most recently, the United States. Physical therapists who do not specialize exclusively in Schroth therapy but who have received Schroth certification through the clinics in Spain and Germany offer Schroth therapy throughout Europe, parts of the Middle East, and the United States.

Surgery

Surgery is usually indicated for curves that have a high likelihood of progression, curves that cause a significant amount of pain with some regularity, curves that would be cosmetically unacceptable as an adult, curves in patients with spina bifida and cerebral palsy that interfere with sitting and care, and curves that affect physiological functions such as breathing.

Surgery for scoliosis is usually done by an orthopaedic surgeon who specializes in spine surgery. For various reasons it is usually impossible to completely straighten a scoliotic spine, but in most cases very good corrections are achieved.

Spinal fusion with instrumentation

Coronal X-ray of the above spine after having undergone successful fusion and instrumentation.

Spinal fusion is the most widely performed surgery for scoliosis. In this procedure, bone (either harvested from elsewhere in the body (autograft), or donor bone (allograft) is grafted to the vertebrae so that when it heals, they will form one solid bone mass and the vertebral column becomes rigid. This prevents worsening of the curve at the expense of spinal movement. This can be performed from the anterior (front) aspect of the spine by entering the thoracic or abdominal cavity, or performed from the back (posterior). A combination of both is used in more severe cases.

Originally, spinal fusions were done without metal implants. A cast was applied after the surgery, usually under traction to pull the curve as straight as possible and then hold it there while fusion took place. Unfortunately, there was a relatively high risk of pseudarthrosis (fusion failure) at one or more levels and significant correction could not always be achieved. In 1962, Paul Harrington introduced a metal spinal system of instrumentation which assisted with straightening the spine, as well as holding it rigid while fusion took place. The original, now obsolete Harrington rod operated on a ratchet system, attached by hooks to the spine at the top and bottom of the curvature that when cranked would distract, or straighten, the curve. A major shortcoming of the Harrington method was that it failed to produce a posture where the skull would be in proper alignment with the pelvis and it didn't address rotational deformity. As a result, unfused parts of the spine would try to compensate for this in the effort to "stand up straight". As the person aged, there would be increased "wear and tear", early onset arthritis, disc degeneration, muscular stiffness and pain with eventual reliance on painkillers, further surgery, inability to work full-time and disability. "Flatback" became the medical name for a related complication, especially for those who had lumbar scoliosis. Modern spinal systems are attempting to address sagittal imbalance and rotational defects unresolved by the Harrington rod system. They involve a combination of rods, screws, hooks and wires fixing the spine and can apply stronger, safer forces to the spine than the Harrington rod. Spinal fusion is rarely performed without this instrumentation.

Modern spinal fusions generally have good outcomes with high degrees of correction and low rates of failure and infection. Patients with fused spines and permanent implants tend to have normal lives with unrestricted activities when they are younger, it remains to be seen whether those that have been treated with the newer surgical techniques will develop problems as they age. They are able to participate in recreational athletics, have natural childbirth and are generally satisfied with their treatment. The most notable limitation of spinal fusions is that patients who have undergone surgery for scoliosis are ineligible for military service in the United States.

In cases where scoliosis has caused a significant deformity resulting in a rib hump, it is often possible to perform a surgery called a "costoplasty" (also called "thorocoplasty") in order to achieve a more pleasing cosmetic result. This procedure may be performed at any time after a fusion surgery, whether as part of the same operation or several years afterwards. As stated before, it is usually impossible to completely straighten and untwist a scoliotic spine, and it should be noted that the level of cosmetic success will depend on the extent to which the fused spine still rotates out into the ribcage. A rib hump is evidence that there is still some rotational deformity to the spine. Specific weight training techniques can be used to influence this rotational deformity in the unfused parts of the spine. This leads to a marked decrease in pain and to some improvement in organ function depending on the person's particular case and is to be recommended over any cosmetic surgical procedure .

Alternatives

Recently, new implants have been developed that aim to delay spinal fusion and to allow more spinal growth in young children. These include rods that are extendible and allow growth while still applying corrective forces and vertebral stapling which is a method of retarding normal growth on the convex side of a curve, allowing the concave side to 'catch up.' For the youngest patients, whose thoracic insufficiency compromises their ability to breathe and applies significant cardiac pressure, ribcage implants that push the ribs apart on the concave side of the curve may be especially useful. These Vertical Expandable Prosthetic Titanium Ribs (VEPTR) provide the benefit of expanding the thoracic cavity and straightening the spine in all three dimensions while allowing the spine to grow. Although these methods are novel and promising, these treatments are only suitable for growing patients. Spinal fusion remains the 'gold-standard' of surgical treatment for scoliosis. There are now non-surgical ways to help treat scoliosis, as mentioned above in the management section.

People known to have scoliosis

• Elizabeth Taylor
• Kurt Cobain
• Hrithik Roshan
• Mohanlal (Malayalam movie actor)
• Brooke Brodack
• Kristin Kreuk
• Princess Eugenie of York
• America Ferrara
• Steve Caballero
• Isabella Rossellini
• Kathakali Banergeee
• Michael McCary
• Rebecca Romijn
• Sarah Michelle Geller
• Chloe Sevigny

Additional references

• Gylys, Barbara A. and Mary Ellen Wedding (2005), Medical Terminology Systems, F.A. Davis Company

• Canale: Campbell's Operative Orthopaedics, 10th ed., Copyright © 2003 Mosby, Inc.

See also

• Kyphosis
• Lordosis
• Alexander Technique
• Spina Bifida

External links

• Scolisois Website by a Scoliosis Patient
• MacLean's Article - Spinecor Treatment
• International Research Society for Spinal Deformities IRSSD
• Scoliosis - Information for Patients
• National Scoliosis Foundation of America
• Scoliosis-Links
• Current research in Scoliosis
• http://www.iscoliosis.com/causes.html
• http://www.kidshealth.org/kid/health_problems/bone/scolio.html