SYT2

SYT2
Identifiers
Aliases	SYT2, SytII, CMS7, MYSPC, synaptotagmin 2, CMS7A, CMS7B
External IDs	OMIM: 600104; MGI: 99666; HomoloGene: 22516; GeneCards: SYT2; OMA:SYT2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,710,454 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,690,331 bp
RNA expression pattern
	Top expressed in
	pons; ; external globus pallidus; ; paraflocculus of cerebellum; ; cerebellar vermis; ; lateral nuclear group of thalamus; ; right hemisphere of cerebellum; ; superior vestibular nucleus; ; pars compacta; ; dorsal motor nucleus of vagus nerve; ; pars reticulata;
	Top expressed in
	cerebellar cortex; ; inferior colliculi; ; medulla oblongata; ; deep cerebellar nuclei; ; pontine nuclei; ; medial vestibular nucleus; ; facial motor nucleus; ; anterior horn of spinal cord; ; cerebellar vermis; ; lobe of cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; inositol 1,3,4,5 tetrakisphosphate binding; clathrin binding; syntaxin binding; protein binding; calcium-dependent phospholipid binding; SNARE binding; phosphatidylserine binding;
Cellular component	cell junction; chromaffin granule membrane; synaptic vesicle; membrane; cytoplasmic vesicle; synapse; integral component of membrane; synaptic vesicle membrane; plasma membrane; clathrin-coated vesicle membrane; axon; dense core granule; exocytic vesicle;
Biological process	synaptic vesicle endocytosis; cell differentiation; neurotransmitter secretion; positive regulation of dendrite extension; vesicle fusion; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; membrane organization; regulation of dopamine secretion; synaptic vesicle exocytosis; vesicle-mediated transport; calcium-ion regulated exocytosis; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
	127833
	20980
	ENSG00000143858
	ENSMUSG00000026452
	Q8N9I0
	P46097
	NM_001136504; NM_177402
	NM_009307; NM_001355726
	NP_001129976; NP_796376
	NP_033333; NP_001342655
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143858 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026452 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232. S2CID 24653745.
^ "Entrez Gene: SYT2 synaptotagmin II".

Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K (November 1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II". The Journal of Biological Chemistry. 269 (46): 29206–11. doi:10.1016/S0021-9258(19)62031-4. PMID 7961887.
Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R (May 1999). "Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells". The Journal of Experimental Medicine. 189 (10): 1649–58. doi:10.1084/jem.189.10.1649. PMC 2193646. PMID 10330444.
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (August 2000). "Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum". The Journal of Cell Biology. 150 (4): 719–30. doi:10.1083/jcb.150.4.719. PMC 2175286. PMID 10952998.
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery". The Journal of Cell Biology. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094.
Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (November 2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II". FEBS Letters. 507 (3): 341–5. doi:10.1016/S0014-5793(01)03000-9. PMID 11696368. S2CID 29026112.
Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O (June 2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1590 (1–3): 159–66. doi:10.1016/S0167-4889(02)00209-4. PMID 12063179.
Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD, Davletov B (March 2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate". The Journal of Biological Chemistry. 279 (13): 12574–9. doi:10.1074/jbc.M310710200. PMID 14709554.
Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH (September 2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding". Molecular Cell. 15 (5): 741–51. doi:10.1016/j.molcel.2004.07.018. PMID 15350218.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143858 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026452 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7749232-5] Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232. S2CID 24653745.

[entrez-6] "Entrez Gene: SYT2 synaptotagmin II".

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References

Further reading