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C. Robin Ganellin

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Charon Robin Ganellin
Born (1934-01-25) 25 January 1934 (age 90)
London, England
CitizenshipUnited Kingdom
Alma materQueen Mary College
Known forCimetidine
Scientific career
FieldsMedicinal Chemistry
InstitutionsUniversity College London

Charon Robin Ganellin FRS (born 25 January 1934) is a British medicinal chemist, and Emeritus Smith Kline and French Professor of Medicinal Chemistry, at University College London.[1][2]

Ganellin has contributed much to the field of drug discovery and development. His most outstanding achievement was the discovery of cimetidine, a drug used to combat stomach ulcers, when he was working at Smith Kline and French.[3] He lives near London and is a professor at University College London.

Early life

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Born in East London, Ganellin knew from an early age that his calling was chemistry. During his studies at Harrow County School for Boys, he developed a strong aptitude for science and maths, but his performance in language and history was lacking. Although he enjoyed biology and natural history above his other subjects, he was influenced to pursue a career in chemistry. As his father and his maternal uncle were chemists, he recognised that chemists could make a living. Uncertain if a career in biology was possible, he decided to become a chemist. He began his formal studies at Queen Mary College in London where he received his first degree, a bachelor of science in chemistry. He continued his studies at Queen Mary College, researching tropylium chemistry with Michael J.S. Dewar where he discovered how to isolate the tropylium cation from cyclooctatetraene. For this research, he was awarded his PhD in organic chemistry in 1958 at age 24.

Scientific work

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In 1958, shortly after his PhD studies at Queen Mary College, Ganellin joined Smith Kline and French Laboratories in the UK where he began research in medicinal chemistry.[3] Two years after starting at SK&F, he went to the Massachusetts Institute of Technology where he performed his postdoctoral work with Arthur C. Cope. At MIT, he devised the first direct optical resolution of a chiral olefin using platinum complex chemistry. After a year at MIT, he returned to the UK to resume his work at SK&F. In 1966, he headed a landmark research team at SK&F, collaborating with Sir James Black researching histamine H2-receptor antagonists. This research eventually led to the discovery of Cimetidine, also known by its trademark name Tagamet which is currently produced by GlaxoSmith Kline. Cimetidine quickly garnered over one billion dollars in annual sales, making it the first blockbuster drug,[4] and it is currently listed by the World Health Organization as one of the most essential drugs.

Awards and achievements

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Since graduating, Robin Ganellin has authored or co-authored over 260 scientific papers and is listed as inventor or co-inventor on over 160 US patents. He has served as the president of the IUPAC medicinal chemistry section, and for 10 years (until 2012) he was the chair of the subcommittee on medicinal chemistry and drug development. He has won many awards and commendations over the years, both for his work on cimetidine and his research in other areas of medicinal chemistry. He has received awards in medicinal chemistry from many organisations, such as the Royal Society of Chemistry, the American Chemical Society, the Society of Chemical Industry, the Society for Drug Research, the European Federation for Medicinal Chemistry, the Société Chimie Thérapeutique of France, and the Medicinal Chemistry Division of the Italian Chemical Society.

He was also inducted into the US National Inventors Hall of Fame in 1990 for his work on cimetidine. Ganellin currently serves as the Emeritus Professor of Medicinal Chemistry, although he is now partially retired.

Drugs List

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[2104-81-6][5] Patent:[6]
  1. Icotidine
  2. Impromidine
  3. Cetiedil (enantiomers):[7]
  4. UCL 1608
  5. Oxmetidine
  6. Cimetidine
  7. UCL-1439
  8. Ciproxifan
  9. UCL-1390
  10. UCL 1684 (pharmacology)
  11. Donetidine
  12. Metiamide
  13. Burimamide
  14. 6-(4-Chlorophenyl)-2,2-dimethylpiperidin-4-one [2104-81-6] (stimulant & depressant properties):[5]
  15. 1-(2-diethylaminoethyl-2-(p-ethoxybenzyl)-2-indene (Ex 9, Nitazene type mimic):[8][9] Patent:[10]

References

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  1. ^ Profile, ucl.ac.uk. Accessed 13 April 2024.
  2. ^ Ganellin, C. Robin (2001). "Professor C. Robin Ganellin FRS". J. Chem. Soc., Perkin Trans. 1. 13 (13): i. doi:10.1039/B101382N.
  3. ^ a b Ganellin, C. Robin. Drug Discovery Today, Feb 2004, Vol. 9 Issue 4, p158, 3p
  4. ^ "Pharmaceutical Sales 101: Me-Too Drugs by Jake Whitney – Guernica / A Magazine of Art & Politics". Archived from the original on 7 August 2008. Retrieved 3 December 2008.
  5. ^ a b Ganellin, C. R.; Spickett, R. G. W. (1965). "Compounds Affecting the Central Nervous System. I. 4-Piperidones and Related Compounds". Journal of Medicinal Chemistry. 8 (5): 619–625. doi:10.1021/jm00329a015.
  6. ^ Ganellin Charon Robin & Spickett Robert Geoffr William, U.S. patent 3,067,204 (1962 to Smith Kline and French Laboratories Ltd).
  7. ^ Roxburgh, Craig J.; Ganellin, C. Robin; Shiner, Mark A. R.; Benton, David C. H.; Dunn, Philip M.; Ayalew, Yeshi; Jenkinson, Donald H. (1996). "The Synthesis and Some Pharmacological Actions of the Enantiomers of the K+-Channel Blocker Cetiedil". Journal of Pharmacy and Pharmacology. 48 (8): 851–859. doi:10.1111/j.2042-7158.1996.tb03986.x.
  8. ^ Ganellin, C. R.; Loynes, J. M.; Ridley, H. F.; Spickett, R. G. W. (1967). "Compounds Affecting the Central Nervous System. IV. Substituted 2-Benzyl-3-dialkylaminoalkylindenes and Related Compounds". Journal of Medicinal Chemistry. 10 (5): 826–833. doi:10.1021/jm00317a016.
  9. ^ Bavin, P. M. G.; Ganellin, C; Loynes, J; Spickett, R G W (1969). "Compounds Affecting the Central Nervous System. V. Substituted 3-Dialkylaminoalkylindenes". Journal of Medicinal Chemistry. 12 (3): 513–516. doi:10.1021/jm00303a608.
  10. ^ Jack David, Spickett Robert Geoffr William & Ganellin Charon Robin, US3159634 (1964 to Smith Kline and French Laboratories Ltd).
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