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Protein-coding gene in the species Homo sapiens
RPS12 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X , 5A2Q , 5AJ0 , 4KZY , 4D61 , 5FLX , 4KZX , 4D5L , 4UJD , 4KZZ , 4UJE , 4UJC
Identifiers Aliases RPS12 External IDs OMIM : 603660 ; MGI : 98105 ; HomoloGene : 110750 ; GeneCards : RPS12 ; OMA :RPS12 - orthologs Wikidata
40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene .[ 5] [ 6] [ 7]
Ribosomes , the organelles that catalyze protein synthesis , consist of a small 40S subunit and a large 60S subunit . Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm . Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[ 7]
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