Prostate cancer folate supplementation: Difference between revisions
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{{Mergeto|Prostate_cancer#Prevention|date=November 2009}}{{No footnotes|article|date=November 2009}} |
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[[Folic acid]] supplements have recently been linked to an increase in risk of developing prostate cancer. Men who take folic acid supplements are more likely to be diagnosed with prostate cancer than men who do not take folic acid supplements. Folate plays a complex role in prostate cancer and folic acid supplements have a different effect on prostate cancer than folate naturally found in foods. |
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Folic acid used in fortified foods is a synthetic form called pteroylmonoglutamate<ref>Smith et al.(2008), 517 </ref>. It is in its oxidized state and contains only one conjugated glutamate residue<ref>Smith et al. (2008), 517</ref>. Folic acid therefore enters via a different carrier system than naturally occurring folate and this may have different effects on folate binding proteins and its transporters<ref>Ulrich et al. (2006)</ref>. |
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Folic acid [[food fortification]] became mandatory in [[Canada]] in 1998, with the fortification of 150ug of folic acid per 100 gram of enriched flour and uncooked cereal grains<ref>Mason et al. (2007), 1325</ref> The purpose of fortification was to decrease the risk of [[neural tube defects]] in [[pregnant]] women. |
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==External links== |
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*{{cite journal |author=Figueiredo JC, Grau MV, Haile RW, ''et al.'' |title=Folic acid and risk of prostate cancer: results from a randomized clinical trial |journal=Journal of the National Cancer Institute |volume=101 |issue=6 |pages=432–5 |year=2009 |month=March |pmid=19276452 |doi=10.1093/jnci/djp019}} |
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* http://health.usnews.com/articles/health/healthday/2009/03/10/folic-acid-supplements-raise-prostate-cancer-risk.html |
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* http://www.medpagetoday.com/HematologyOncology/ProstateCancer/13204 |
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* http://www.thaindian.com/newsportal/health/folic-acid-supplements-raise-prostate-cancer-risk_100165131.html |
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* http://www.cbc.ca/health/story/2009/03/10/folic-acid-prostate-cancer.html |
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* http://www.theglobeandmail.com/life/article976033.ece |
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* http://www.boston.com/news/nation/washington/articles/2009/03/11/more_folic_acid_may_raise_prostate_cancer_risk/ |
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* http://www.nutraingredients.com/Research/Study-raises-concerns-over-folic-acid-and-prostate-cancer |
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* http://healthnow.usc.edu/2009/03/prostate-predicament.html |
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Mason, J. B., Dickstein, A., Jacques, P. F., Haggarty, P., Selhub, J., Dallal, G., et al. (2007). A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: A hypothesis. Cancer Epidemiology Biomarkers & Prevention, 16(7), 1325. |
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Smith, A. D., Kim, Y. I., & Refsum, H. (2008). Is folic acid good for everyone? American Journal of Clinical Nutrition, 87(3), 517. |
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Ulrich, C.M. and Potter, J.D. (2006). Folate supplementation: Too much of a good thing? Retrieved 11/12, 2009, from http://cebp.aacrjournals.org/content/15/2/189 |
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