London Underground mosquito

Culex pipiens f. molestus
Scientific classification
Domain:	Eukaryota
Kingdom:	Animalia
Phylum:	Arthropoda
Class:	Insecta
Order:	Diptera
Family:	Culicidae
Genus:	Culex
Species:	C. pipiens
Form:	C. p.  f. molestus
Trionomial name
Culex pipiens f. molestus

The London Underground mosquito, Culex pipiens f. molestus, is a form of mosquito which assaulted people sleeping in the London Underground railway system during the Blitz. It has a worldwide distribution and long predates the existence of the London Underground. It was first described in the 18th century based on Egyptian specimens by the biologist Peter Forsskål (1732–1763). He named it Culex molestus due to its voracious biting, but later biologists reclassified it as Culex pipiens f. molestus because there were no morphological differences between it and Culex pipiens.

A study from 2004 analyzing DNA microsatellites suggested that it might be a distinct species, but a paper from 2012 found it to be "a physiological and ecological variant of Cx. pipiens" which should not be considered a distinct species. As of 2024, the consensus among researchers is that it is not a distinct species, but a form of Culex pipiens, which is often referred to as Culex pipiens f. molestus.

Description

Londoners sheltering from the Blitz in underground stations suffered from mosquito bites

This mosquito is found in underground systems around the world. Although some authors have proposed that it is a new species that evolved since the 19th century from local above-ground Culex pipiens in adaptation to human-made underground systems, it is more likely that C. pipiens f. molesta, which has been in existence for at least hundreds of years, recently colonized the warm underground spaces of northern cities.

Behavioral evidence that it is a distinct form of C. pipiens comes from research by Kate Byrne and Richard Nichols. The forms have very different behaviours, are extremely difficult to mate, and with different allele frequencies consistent with genetic drift during a founder event. Specifically, C. pipiens f. molestus, breeds all-year round, is cold intolerant, and bites rats, mice, and humans, in contrast to the above-ground form, which is cold tolerant, hibernates in the winter, and is considered to mostly feed on bird hosts. When the two forms were crossbred by Byrne and Nichols, the eggs were infertile, suggesting reproductive isolation.

Hosts

The mosquito has been documented to feed upon birds.

Parasites

For decades Cx. pipiens f. molestus was known as a fully competent host of only one kind of malaria, Plasmodium garnhami. Only this Plasmodium had been demonstrated to complete sporogony by Garnham 1966. Due to this lack of study a team investigated whether a more common kind of malaria could also go through the life cycle. Žiegytė et al. 2014 find that P. relictum also completes sporogony in Cx. pipiens f. molestus. They also discovered that two P. relictum strains differing only by one base pair produced markedly different parasitemia of the insect; pGRW11 much more than pSGS1.

Heredity

Genetic data indicate that different groups of C. pipiens f. molestus in the London Underground have a common ancestry, rather than the population at each station being related to the nearest above-ground population. Byrne and Nichols concluded that it was plausible that there was a single colonization of the London Underground.

Genetic evidence reported by Fonseca and others suggests a single C. pipiens f. molestus form has spread throughout Europe and beyond, since populations over a large area share a common genetic heritage. These widely separated populations are distinguished by minor genetic differences; a single mtDNA difference is shared among the underground populations of 10 Russian cities, and a single fixed microsatellite difference occurs in populations spanning Europe, Japan, Australia, the Middle East, and the Atlantic islands. This worldwide spread might have occurred after the last glaciations or may be even more recent.

Also, the Fonseca paper argued that the colonization of America by Culex mosquitoes involved a strain derived from a hybrid of "genetically distinct entities:" C. pipiens and another which, "for the sake of brevity," they called "C. molestus". They suggested that hybridization might explain why the American form bites both birds and humans (this interpretation is controversial, see letter from Spielman et al. and the response that follows it in Science). The consequences of its indiscriminate feeding hit the news in 1999 with the outbreak of human encephalitis in New York, caused by West Nile virus. It was the first documented introduction of this virus into the Western Hemisphere; perhaps because in the longer established populations, the Old World northern above-ground C. pipiens almost exclusively bites birds, with the human-biting ones being incarcerated below ground.

Distribution

Culex pipiens f. molestus has been observed in North and South America, Europe, Asia, Africa, and Australasia. It was first described in Egypt in the late 1700s, and has likely spread via trade and colonial passages over the past centuries.

In the summer of 2011, an invasion of Culex pipiens f. molestus appeared on the Upper West Side in Manhattan, New York City. The mosquito is well known for being commonly found in sewers of New York and thriving throughout the year feeding on humans. Residents of older brownstones found the mosquitoes coming into basements and then through air vents and other openings into their homes. The city government did not make this infestation of the pest a top priority because they tested negative for West Nile virus and because of the high cost of mosquito control.

In Australia, Culex pipiens f. molestus was first recorded in the 1940s, and has since spread across all southern states, causing a significant biting nuisance in urban areas. Unlike most Australian urban mosquitos, it is active through all 12 months of the year. Its introduction was likely through military movements into Melbourne during World War II, and genetic studies have indicated its most likely passage was from eastern Asia and Japan. It has also been identified as a potential vector for several Australian blood-borne diseases, such as Ross River virus.