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PRAM1

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PRAM1
Identifiers
AliasesPRAM1, PML-RAR, PRAM-1, PML-RARA regulated adaptor molecule 1
External IDsOMIM: 606466; MGI: 3576625; HomoloGene: 12963; GeneCards: PRAM1; OMA:PRAM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032152

NM_001002842

RefSeq (protein)

NP_115528

NP_001002842

Location (UCSC)Chr 19: 8.49 – 8.5 MbChr 17: 33.86 – 33.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.[5][6][7]

Function

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The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).[7]

Interactions

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PRAM1 has been shown to interact with TRIM27.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133246Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032739Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G (Jun 2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J Biol Chem. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.
  6. ^ Clemens RA, Newbrough SA, Chung EY, Gheith S, Singer AL, Koretzky GA, Peterson EJ (Dec 2004). "PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function". Mol Cell Biol. 24 (24): 10923–32. doi:10.1128/MCB.24.24.10923-10932.2004. PMC 533979. PMID 15572693.
  7. ^ a b "Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1".
  8. ^ Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD (May 1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell Sci. 111 (10): 1319–29. doi:10.1242/jcs.111.10.1319. PMID 9570750.

Further reading

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