POLR1E

POLR1E
Identifiers
Aliases	POLR1E, PAF53, PRAF1, polymerase (RNA) I subunit E, RNA polymerase I subunit E, A49, RPA49
External IDs	MGI: 1929022; HomoloGene: 41486; GeneCards: POLR1E; OMA:POLR1E - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	37,503,697 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	45,036,565 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; left ovary; ; Achilles tendon; ; gonad; ; body of uterus; ; right ovary; ; secondary oocyte; ; ganglionic eminence; ; ectocervix; ; left uterine tube;
	Top expressed in
	otic placode; ; saccule; ; embryo; ; otic vesicle; ; spermatocyte; ; morula; ; epiblast; ; embryo; ; tail of embryo; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; DNA binding; RNA polymerase I general transcription initiation factor binding; RNA polymerase I activity;
Cellular component	nucleus; nucleoplasm; fibrillar center; nucleolus; RNA polymerase I complex;
Biological process	transcription initiation from RNA polymerase I promoter; termination of RNA polymerase I transcription; epigenetic maintenance of chromatin in transcription-competent conformation; transcription, DNA-templated; RNA polymerase I preinitiation complex assembly; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	64425
	64424
	ENSG00000137054
	ENSMUSG00000028318
	Q9GZS1
	Q8K202
	NM_001282766; NM_022490
	NM_001285800; NM_022811
	NP_001269695; NP_071935
	NP_001272729; NP_073722
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase I subunit RPA49 is an enzyme that in humans is encoded by the POLR1E gene.^[5]^[6]

Interactions

POLR1E has been shown to interact with CD3EAP^[7] and POLR1C.^[8]^[7]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137054 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028318 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanada K, Song CZ, Yamamoto K, Yano K, Maeda Y, Yamaguchi K, Muramatsu M (May 1996). "RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription". The EMBO Journal. 15 (9): 2217–26. doi:10.1002/j.1460-2075.1996.tb00575.x. PMC 450146. PMID 8641287.
^ "Entrez Gene: POLR1E polymerase (RNA) I polypeptide E, 53kDa".
^ ^a ^b Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Seither P, Zatsepina O, Hoffmann M, Grummt I (Sep 1997). "Constitutive and strong association of PAF53 with RNA polymerase I". Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID 9254723. S2CID 23487728.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Seither P, Zatsepina O, Hoffmann M, Grummt I (Sep 1997). "Constitutive and strong association of PAF53 with RNA polymerase I". Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID 9254723. S2CID 23487728.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Voit R, Grummt I (Nov 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 13631–6. Bibcode:2001PNAS...9813631V. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Bjerregaard B, Wrenzycki C, Strejcek F, Laurincik J, Holm P, Ochs RL, Rosenkranz C, Callesen H, Rath D, Niemann H, Maddox-Hyttel P (Apr 2004). "Expression of nucleolar-related proteins in porcine preimplantation embryos produced in vivo and in vitro". Biology of Reproduction. 70 (4): 867–76. doi:10.1095/biolreprod.103.021683. PMID 14585813.
Baran V, Pavlok A, Bjerregaard B, Wrenzycki C, Hermann D, Philimonenko VV, Lapathitis G, Hozak P, Niemann H, Motlik J (Apr 2004). "Immunolocalization of upstream binding factor and pocket protein p130 during final stages of bovine oocyte growth". Biology of Reproduction. 70 (4): 877–86. doi:10.1095/biolreprod.103.018408. PMID 14613906. S2CID 43563796.
Bjerregaard B, Wrenzycki C, Philimonenko VV, Hozak P, Laurincik J, Niemann H, Motlik J, Maddox-Hyttel P (Apr 2004). "Regulation of ribosomal RNA synthesis during the final phases of porcine oocyte growth". Biology of Reproduction. 70 (4): 925–35. doi:10.1095/biolreprod.103.020941. PMID 14627545.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
Percipalle P, Fomproix N, Cavellán E, Voit R, Reimer G, Krüger T, Thyberg J, Scheer U, Grummt I, Farrants AK (May 2006). "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Reports. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC 1479564. PMID 16514417.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137054 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028318 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8641287-5] Hanada K, Song CZ, Yamamoto K, Yano K, Maeda Y, Yamaguchi K, Muramatsu M (May 1996). "RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription". The EMBO Journal. 15 (9): 2217–26. doi:10.1002/j.1460-2075.1996.tb00575.x. PMC 450146. PMID 8641287.

[entrez-6] "Entrez Gene: POLR1E polymerase (RNA) I polypeptide E, 53kDa".

[pmid15226435-7] Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid9254723-9] Seither P, Zatsepina O, Hoffmann M, Grummt I (Sep 1997). "Constitutive and strong association of PAF53 with RNA polymerase I". Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID 9254723. S2CID 23487728.

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Interactions

References

Further reading