PLVAP

PLVAP
Identifiers
Aliases	PLVAP, FELS, PV-1, PV1, gp68, plasmalemma vesicle associated protein, DIAR10
External IDs	OMIM: 607647; MGI: 1890497; HomoloGene: 10578; GeneCards: PLVAP; OMA:PLVAP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,377,342 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,964,396 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; epithelium of colon; ; gallbladder; ; pericardium; ; cardia; ; tendon of biceps brachii; ; subcutaneous adipose tissue; ; spleen; ; fundus;
	Top expressed in
	right lung; ; right lung lobe; ; mesenteric lymph nodes; ; atrium; ; right kidney; ; endothelial cell of lymphatic vessel; ; islet of Langerhans; ; left lung; ; spleen; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; caveola; integral component of membrane; cell surface; plasma membrane; extracellular exosome; membrane;
Biological process	tumor necrosis factor-mediated signaling pathway; protein kinase C signaling; MAPK cascade; positive regulation of cellular extravasation; developmental process;
	Sources:Amigo / QuickGO
Orthologs
	83483
	84094
	ENSG00000130300
	ENSMUSG00000034845
	Q9BX97
	Q91VC4
	NM_031310
	NM_032398
	NP_112600
	NP_115774
	Wikidata
View/Edit Human	View/Edit Mouse

Plasmalemma vesicle-associated protein is a protein that in humans is encoded by the PLVAP gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130300 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034845 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.
^ "Entrez Gene: PLVAP plasmalemma vesicle associated protein".

Stan RV, Ghitescu L, Jacobson BS, Palade GE (1999). "Isolation, Cloning, and Localization of Rat PV-1, a Novel Endothelial Caveolar Protein". J. Cell Biol. 145 (6): 1189–98. doi:10.1083/jcb.145.6.1189. PMC 2133139. PMID 10366592.
Hnasko R, McFarland M, Ben-Jonathan N (2003). "Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands". J. Endocrinol. 175 (3): 649–61. CiteSeerX 10.1.1.322.5434. doi:10.1677/joe.0.1750649. PMID 12475376.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Stan RV, Tkachenko E, Niesman IR (2005). "PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms". Mol. Biol. Cell. 15 (8): 3615–30. doi:10.1091/mbc.E03-08-0593. PMC 491823. PMID 15155804.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strickland LA, Jubb AM, Hongo JA, et al. (2005). "Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)". J. Pathol. 206 (4): 466–75. doi:10.1002/path.1805. PMID 15971170. S2CID 45045679.
Carson-Walter EB, Hampton J, Shue E, et al. (2006). "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis". Clin. Cancer Res. 11 (21): 7643–50. doi:10.1158/1078-0432.CCR-05-1099. PMID 16278383.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130300 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034845 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11401446-5] Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.

[entrez-6] "Entrez Gene: PLVAP plasmalemma vesicle associated protein".

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References

Further reading