PLA2G2A

PLA2G2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AYP, 1BBC, 1DB4, 1DB5, 1DCY, 1J1A, 1KQU, 1KVO, 1N28, 1N29, 1POD, 1POE, 3U8B, 3U8D, 3U8H, 3U8I
Identifiers
Aliases	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2, phospholipase A2 group IIA
External IDs	OMIM: 172411; MGI: 104642; HomoloGene: 254; GeneCards: PLA2G2A; OMA:PLA2G2A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	19,980,416 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,562,497 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; pericardium; ; right coronary artery; ; tendon of biceps brachii; ; mucosa of ileum; ; synovial joint; ; gastric mucosa; ; right auricle; ; left coronary artery; ; rectum;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; duodenum; ; jejunum; ; Paneth cell; ; ankle joint; ; Ileal epithelium; ; morula; ; gastrula; ; intercostal muscle; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; calcium-dependent phospholipase A2 activity; metal ion binding; hydrolase activity; phospholipid binding; phospholipase A2 activity;
Cellular component	membrane; endoplasmic reticulum membrane; secretory granule; endoplasmic reticulum; perinuclear region of cytoplasm; extracellular exosome; extracellular region; plasma membrane; extracellular space;
Biological process	phosphatidic acid biosynthetic process; phosphatidylserine acyl-chain remodeling; positive regulation of inflammatory response; phosphatidylethanolamine acyl-chain remodeling; lipid metabolism; phosphatidylinositol acyl-chain remodeling; lipid catabolic process; positive regulation of macrophage derived foam cell differentiation; low-density lipoprotein particle remodeling; positive regulation of ERK1 and ERK2 cascade; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid metabolic process; phosphatidylcholine acyl-chain remodeling; defense response to Gram-positive bacterium; phospholipid metabolic process; antimicrobial humoral response; arachidonic acid secretion;
	Sources:Amigo / QuickGO
Orthologs
	5320
	18780
	ENSG00000188257
	ENSMUSG00000058908
	P14555
	P31482
	NM_001161729; NM_000300; NM_001161727; NM_001161728; NM_001395463
	NM_001082531; NM_011108
	NP_000291; NP_001155199; NP_001155200; NP_001155201
	NP_001076000
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase A₂, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188257 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058908 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ (Feb 1997). "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human". Genomics. 32 (3): 328–33. doi:10.1006/geno.1996.0126. PMID 8838795.
^ "Entrez Gene: PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid)".

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