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PKD2L1

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(Redirected from PKD2L1 (gene))
PKD2L1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDsOMIM: 604532; MGI: 1352448; HomoloGene: 22946; GeneCards: PKD2L1; OMA:PKD2L1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253837
NM_016112

NM_181422

RefSeq (protein)

NP_001240766
NP_057196

NP_852087

Location (UCSC)Chr 10: 100.29 – 100.33 MbChr 19: 44.14 – 44.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 2 (TRPP2; formerly TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.[5]

Function

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TRPP2 is a member of the polycystin protein family. TRPP2 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP2 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP2 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.[5]

Interactions

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PKD2L1 has been shown to interact with TNNI3.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107593Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037578Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1".
  6. ^ Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ (June 2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry. 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519.

Further reading

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