PJA1

PJA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L0B
Identifiers
Aliases	PJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1
External IDs	OMIM: 300420; MGI: 1101765; HomoloGene: 129620; GeneCards: PJA1; OMA:PJA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	69,165,521 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	98,514,879 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; corpus epididymis; ; ventricular zone; ; nucleus accumbens; ; middle temporal gyrus; ; anterior cingulate cortex; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; Brodmann area 9; ; caudate nucleus;
	Top expressed in
	corneal stroma; ; CA3 field; ; perirhinal cortex; ; entorhinal cortex; ; Ileal epithelium; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	cytoplasm;
Biological process	protein catabolic process; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	64219
	18744
	ENSG00000181191
	ENSMUSG00000034403
	Q8NG27
	O55176
	NM_001032396; NM_022368; NM_145119; NM_001382775; NM_001382776
	NM_001083110; NM_001290555; NM_001290556; NM_008853
	NP_001027568; NP_071763; NP_660095; NP_001369704; NP_001369705
	NP_001076579; NP_001277484; NP_001277485; NP_032879
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.^[5]^[6]

Interactions

PJA1 has been shown to interact with UBE2D2^[5] and MAGED1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181191 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034403 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
^ "Entrez Gene: PJA1 praja 1".
^ Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, et al. (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (March 2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". The Journal of Biological Chemistry. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181191 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034403 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12036302-5] Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.

[entrez-6] "Entrez Gene: PJA1 praja 1".

[pmid11959851-7] Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

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Interactions

References

Further reading